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Tyrer-Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma. [PDF]

Breast J
Rao D, Wernecke C, Baron L, Cai S, Beitsch P, Patel R, Whitworth P, Rosen B, Tran NN, Hughes K, Baron PL.   +10 more
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BRCA-mutant pancreatic ductal adenocarcinoma

British Journal of Cancer, 2021
Despite continued research, pancreatic ductal adenocarcinoma (PDAC) remains one of the main causes of cancer death. Interest is growing in the role of the tumour suppressors breast cancer 1 (BRCA1) and BRCA2-typically associated with breast and ovarian cancer-in the pathogenesis of PDAC. Indeed, both germline and sporadic mutations in BRCA1/2 have been
Lai E., Ziranu P., Spanu D., Dubois M., Pretta A., Tolu S., Camera S., Liscia N., Mariani S., Persano M., Migliari M., Donisi C., Demurtas L., Pusceddu V., Puzzoni M., Scartozzi M.   +15 more
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BRCA-1, BRCA-2 and Hereditary Breast Cancer

2002
I. INTRODUCTION The etiology of breast cancer is multifactorial, involving environmental factors, hormones, genetic susceptibility, and genetic changes during progression. Mutations in a number of genes are known to cause susceptibility to breast cancer.
Betsy Bove, Roland Dunbrack, Andrew Godwin   +2 more
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Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues

Hormone Molecular Biology and Clinical Investigation, 2020
Abstract Objectives Genetic testing rates for hereditary breast and ovarian cancer (HBOC) have steadily increased during the past decades resulting in a growing population of young and healthy mutation carriers.
Laura Knabben, Franziska Siegenthaler, Sara Imboden, Michael D. Mueller   +3 more
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BRCA Breakthrough

Science of Aging Knowledge Environment, 2002
Cracking a stubborn mystery, a new study pins down the function of BRCA2, the DNA-repair protein that goes awry in many cases of breast cancer. The mammoth molecule holds onto a cracked DNA strand while a protein partner fixes the damage. The findings promise to illuminate how flaws in BRCA2 provoke cancer. Mutations in
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The Fanconi anaemia/BRCA pathway

Nature Reviews Cancer, 2003
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1 ...
Alan D, D'Andrea, Markus, Grompe
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When the BRCA test is negative—Prevention strategies in women who have no detectable mutation (BRCA-) compared to women harboring positive BRCA mutations (BRCA+)

Journal of Clinical Oncology, 2008
1534 Background: Much attention has been focused on screening and risk reduction, including prophylactic mastectomy (PM) or oophorectomy (PO) in BRCA+ mutation carriers (Rebbeck 1999, Eisen 2005, Kauff 2007). In families with a known BRCA mutation (BRCA+) or a history of hereditary breast cancer (BC) or ovarian cancer (OC), relatives in whom a mutation
S. Verma, S. F. Dent, L. Paquet, L. Bitonti   +3 more
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BRCA Patient Population

2016
Less than 10 % of breast cancers are due to hereditary triggers. The majority are hereditary mutations in single, dominant genes although more recent hypotheses are suggesting the implication of yet unidentified genes in a larger proportion of the sporadic cluster of breast cancers.
Alain Mina, Lida A. Mina
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