Results 211 to 220 of about 65,986 (255)

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

JAK2^V617F-positive clonal hematopoiesis in germline BRCA1 versus BRCA2 mutation carriers. [PDF]

Leukemia
Rodriguez MJ, Hauke J, Kayali M, Baumeister J, de Toledo MAS, Engel C, Meyer R, Hubens W, Wagner W, Wessiepe M, Schmutzler RK, Rhiem K, Brümmendorf TH, Elbracht M, Hahnen E, Koschmieder S.   +15 more
europepmc   +1 more source

Relating transcriptomics to protein abundance reveals self‐driven versus interactor‐driven proteins

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Statistically modeling the interdependence between transcriptomics and protein abundances remains a persistent challenge in bioinformatics research. Transcriptomic data and proteomic abundances typically display a moderate Pearson's correlation of about 0.5, while in tumor conditions, the correlation may decrease to a much weaker correlation ...
Loulwah Arnaout, Volkhard Helms, Aram Papazian   +2 more
wiley   +1 more source

ConMIL: interactive and contrastive text-guided multiple instance learning for whole slide image classification. [PDF]

Bioinformatics
Han A, Jolley A, Butler LM, Chen W.
europepmc   +1 more source

Environmental Asbestos Exposure as a Possible Pathway to Early‐Onset Pleural Mesothelioma: A Case From Afghanistan and Pakistan to London

Respirology Case Reports, Volume 14, Issue 10, October 2026.
We report a case of a 40‐year‐old male with malignant pleural mesothelioma with no prior occupational exposure to asbestos. Environmental exposure as a cause of MPM may come into focus through migration from high environmental asbestos exposure regions in patients with no known occupational exposure.
Sophie Mounouchos, Asmita Aggarwal, Asaad Ahmed Nafees, Emma Johnson, Paul Cullinan, Carl Reynolds   +5 more
wiley   +1 more source

Integrated Bioinformatics Analysis Identifies NCAPG2 as an Immune-Related Prognostic Biomarker in Breast Cancer. [PDF]

World J Oncol
Li J, Wang Q, Qiao H.
europepmc   +1 more source

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, Volume 138, Issue 4, Page 600-606, October 2026.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source

Slide Selection Introduces Sampling-Induced Prediction Uncertainty in Digital Pathology AI: Evidence from Multi-Slide Breast Cancer Cohorts. [PDF]

Cancers (Basel)
Koyun OC, Guo Y, Lu H, Demir MF, Alili A, Rahoui N, Cardona D, Gurcan MN.   +7 more
europepmc   +1 more source

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, Volume 117, Issue 10, Page 2803-2818, October 2026.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

Clinical Evaluation of HHLA2 in Hormone Receptor-Positive Breast Cancer: Expression Patterns and Prognostic Implications. [PDF]

Biomedicines
Kwon MJ, Yi JM, Kim TH, Park HY.
europepmc   +1 more source