British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng +10 more
wiley +1 more source
Reproductive medicine care in BRCA mutation carriers: an opportunity for early intervention. [PDF]
F S RepEsencan E, Goldman KN.
europepmc +1 more source
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source
Malignant vs. Non-malignant Annotations on TCGA Breast Cancer Whole Slide Images for AI Analysis. [PDF]
Sci DataShahraki ZA +5 more
europepmc +1 more source
Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras +9 more
wiley +1 more source
Later-generation epigenetic aging clocks outperform first-generation models in predicting survival in TCGA breast cancer. [PDF]
Clin EpigeneticsTan X, Pellegrini M, Jung SY.
europepmc +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT This study aimed to elucidate the mechanism of action of Schisandrin A in the intervention of triple‐negative breast cancer (TNBC). Through the application of network pharmacology and the integration of targets from multiple databases, the research identified 128 overlapping targets between Schisandrin A and TNBC.
Meng Xu +6 more
wiley +1 more source
Macrophage-associated prognostic modeling uncovers immunotherapy response mechanisms and defines HAGHL as a novel oncogenic driver in breast cancer. [PDF]
Front ImmunolPei S +8 more
europepmc +1 more source
Dual PARP/Tankyrase Inhibition Enhances Antitumor Efficacy in PTEN‐Deficient Endometrial Cancer
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Endometrial cancer (EC) incidence continues to rise, underscoring the need for effective therapies beyond BRCA‐mutant disease. Although PTEN loss, a frequent alteration in EC, has been implicated in impaired homologous recombination and increased sensitivity to PARP inhibitors, responses to PARP inhibitor monotherapy remain variable and are ...
Sung Wan Kang +6 more
wiley +1 more source
A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair-deficient breast or ovarian cancer. [PDF]
BJC RepCamacho-Valenzuela J +9 more
europepmc +1 more source