Results 181 to 190 of about 95,123 (282)

Microbial metabolite 5-formamidoimidazole-4-carboxamide ribotide targets METTL1 to inhibit m7G modification of BRCA1 mRNA to inhibit high-grade serous ovarian cancer. [PDF]

Mol Med
Chen L, He S.
europepmc   +1 more source

Drastic Response to Olaparib in a Patient With Metastatic Castration‐Resistant Prostate Cancer Harboring BRCA2 Alterations and Near‐Threshold Tumor Mutational Burden

IJU Case Reports, Volume 9, Issue 2, March 2026.
ABSTRACT Introduction BRCA2 alterations and high tumor mutational burden (TMB‐H) are responsible for prostate cancer; however, their co‐occurrence is uncommon, and evidence for PARP inhibition in the castration‐sensitive setting remains limited. We describe a case of metastatic castration‐resistant prostate cancer (CRPC) harboring both biomarkers ...
Kotaro Yokota, Takeo Kosaka, Tatsuaki Daimon, Shinnosuke Fujiwara, Kohei Nakamura, Hiroshi Nishihara, Mototsugu Oya   +6 more
wiley   +1 more source

Hereditary ovarian cancer in women with African ancestry: a scoping review. [PDF]

Fam Cancer
Rossouw B, Araujo M, Krause A, Baine-Savanhu F.   +3 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Functional assessment of protein variants in structured domains by fluorescence cross-correlation spectroscopy. [PDF]

Sci Rep
Mateu-Regué À, Mariani L, Bagger FO, Bose M, Nielsen FC.   +4 more
europepmc   +1 more source

Diagnostic Accuracy of O‐RADS US, IOTA Simple Rules, Subjective Assessment, and the Sequential IOTA Simple Rules–Subjective Assessment (SR–SA) Strategy in Adnexal Masses: High Sensitivity Versus the Challenge of Specificity in a Middle‐Resource Setting

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Objectives To compare four ultrasound models: O‐RADS US, IOTA Simple Rules (SR), Subjective Assessment (SA), and the Sequential SR–Subjective Assessment strategy (SR–SA) for classifying adnexal masses and to assess whether additional discrimination is possible within intermediate‐risk O‐RADS 3 lesions in a middle‐resource setting.
Carolina Meloni Stecca, Paula Meneguini Badran, Maira Furtado Greco Mazzer, Rodrigo Menezes Jales   +3 more
wiley   +1 more source

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biol
Wang L, Wu X, Paul A, Yao J, Wang B.
europepmc   +1 more source

Experiences of metastatic prostate cancer patients with a mainstream genetic testing pathway

International Journal of Cancer, Volume 158, Issue 4, Page 984-993, 15 February 2026.
What's new? Germline genetic testing can direct cancer patients towards more optimal treatment options and relatives towards targeted cancer screening or preventive measures. In the case of prostate cancer, many patients are eligible for such testing, though little is known about its psychosocial impacts.
Michiel Vlaming, Eveline M. A. Bleiker, Gina Schijven, Lambertus A. L. M. Kiemeney, Harm H. E. van Melick, Jarmo C. B. Hunting, M. Arjen Noordzij, Aart Beeker, Diederik M. Somford, Henk G. van der Poel, Carl J. Wijburg, Bart P. Wijsman, Robert J. Hoekstra, R. Jeroen A. van Moorselaar, Bart P. J. van Bezooijen, Richard P. Meijer, Martijn B. Busstra, H. Pieter van den Berg, Debbie G. J. Robbrecht, Benjamin H. J. Doornweerd, Inge M. van Oort, Margreet G. E. M. Ausems   +21 more
wiley   +1 more source

Retraction Note: BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1. [PDF]

Sci Rep
Zhang W, Luo J, Yang F, Wang Y, Yin Y, Strom A, Gustafsson JÅ, Guan X.   +7 more
europepmc   +1 more source

microRNA 146a suppresses tumor progression and enhances therapeutic sensitivity by targeting the EGFR pathway in BRCA1-associated basal-like breast cancers

Roy A. Jensen, Easwari Kumaraswamy, Raeann M. Shimak, Sumedha Gunewardena, Dani Alexander, Karen Wendt, Stacey L. Hembruff   +6 more
openalex   +1 more source