Results 91 to 100 of about 104,745 (290)

Contribution of BRCA1 and BRCA2 germline mutations to early onset breast cancer: a series from north of Morocco [PDF]

, 2020
Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, Elmostafa El Fahime, Amina Barakat, Naima Ghailani Nourouti, Jaime Martínez de Villarreal, Carlos Bringas, Mohcine Bennani Mechita   +9 more
openalex   +1 more source

Interpretation of BRCA2 Splicing Variants: A Case Series of Challenging Variant Interpretations and the Importance of Functional RNA Analysis [PDF]

, 2021
Paola Nix, Erin Mundt, Bradford Coffee, Elizabeth Goossen, Bryan M. Warf, Krystal Brown, Karla R. Bowles, Benjamin B. Roa   +7 more
openalex   +1 more source

BMI and Breast Subcutaneous Fat

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obesity is closely associated with the occurrence and progression of breast cancer. While body mass index (BMI) is widely used to diagnose obesity, it has certain limitations. Subcutaneous fat thickness (SFT) also serves as an indicator of body composition. However, studies on breast SFT are scarce.
Shiyu Wang, Jin Zhou, Yunxia Huang, Dongdong Zheng, Ruoqing Hou, Shichong Zhou   +5 more
wiley   +1 more source

Features and complexity of treatment of BRCA-associated ovarian cancer, chronic disease: literature review

Опухоли женской репродуктивной системы
We analyzed literature data on the peculiarities of the clinical manifestation and therapeutic approaches ofB RCA-associated ovarian carcinomas. The ESMO-ESGO consensus emphasised the importance of determining BRCA1/2 status in ovarian cancer patients ...
T. V. Gorodnova, A. P. Sokolenko, Kh. B. Kotiv, I. V. Berlev, E. N. Imyanitov   +4 more
doaj   +1 more source

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. [PDF]

, 2010
BRCA2 is a tumor suppressor that functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on single-stranded DNA (ssDNA) to perform homology search and
Doty, Tammy, Gibson, Bryan, Heyer, Wolf-Dietrich, Liu, Jie   +3 more
core   +2 more sources

Supplementary Figure 6 from Perturbation of Rb, p53, and Brca1 or Brca2 Cooperate in Inducing Metastatic Serous Epithelial Ovarian Cancer [PDF]

, 2023
Ludmila Szabova, Chaoying Yin, Sujata Bupp, Theresa M. Guerin, Jerome Schlomer, Deborah B. Householder, Maureen Baran, Ming Yi, Yurong Song, Wenping Sun, Jonathan E. McDunn, Philip Martin, Terry Van Dyke, Simone Difilippantonio   +13 more
openalex   +1 more source

Compliance of Dermatology Screening Visits Among Patients With Skin Cancer‐Predisposing Pathogenic Variants

JEADV Clinical Practice, EarlyView.
Patients with genetic variants that increase skin cancer risk are recommended to undergo regular dermatology screenings per National Comprehensive Cancer Network guidelines, but compliance is uncertain. In a retrospective study of 230 patients with such variants, compliance with screening visits significantly improved after visiting a Hereditary Cancer
Stephen J. Gadomski, Kevin S. Hughes, Jihad S. Obeid, Courtney Rowley, Graciela De Jesús   +4 more
wiley   +1 more source

El cáncer hereditario en mujeres

Arbor: Ciencia, Pensamiento y Cultura, 2015
La mayoría de los casos de cáncer son esporádicos, entre un 20-30% presentan agregación familiar, mientras que solo el 5 -10% son de carácter hereditario.
Rafael Morales Chamorro, Isabel Chirivella González, Gemma Llort Pursals, Ana Beatriz Sánchez Heras, Raquel Serrano Blanch, Alexandre Teule Vega, Carmen Guillén Ponce, Begoña Graña Suárez   +7 more
doaj   +1 more source

Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy [PDF]

, 2018
Aim: Male breast cancer (MBC) is a rare disease and recommendations for its clinical management are often extrapolated from those for female breast cancer, even if breast cancer (BC) has different characteristics in the two sexes.
Bendinelli, Benedetta, Bianchi, Simonetta, Magrini, Alessandro, Masala, Giovanna, Ottini, Laura, Palli, Domenico, Rizzolo, Piera, Saieva, Calogero, Silvestri, Valentina, Valentini, Virginia, Vezzosi, Vania, Zanna, Ines, Zelli, Veronica   +12 more
core   +1 more source

Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation

The Prostate, EarlyView.
ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama, Violet A. Daniels, Marta Gielzak, Alex Brame, Misop Han, Li Jia, Jianfeng Xu, Tamara L. Lotan, Mario A. Eisenberger, Catherine H. Marshall, Patrick C. Walsh, William B. Isaacs, Jun Luo   +12 more
wiley   +1 more source