BRCA1 and BRCA2 screening of nine Chilean founder mutations through allelic-discrimination and real-time PCR in breast/ovarian cancer patients [PDF]
, 2022 Carolina Álvarez +3 more
openalex +1 more source
Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame
Allergy, EarlyView.This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat +16 more
wiley +1 more source
Balkan Journal of Medical GeneticsThe purpose of our study is to expedite cancer diagnosis through the development of software for rapid detection of hereditary breast cancer (BC) with negative BRCA1/2 on MATLAB, utilizing a fuzzy logic system with several variants of genes associated ...
Senturk N +8 more
doaj +1 more source
Tactics of radiographic diagnostics of breast cancer in women with inherited predisposition
Опухоли женской репродуктивной системы, 2015 With conventional approaches to mammography tissue examination in women over 40 years of age, mammography has been found to be lesseffective for a group of younger women with negative family histories (cancer in the family) and BRCA1 and BRCA2 gene ...
M. S. Karpova +2 more
doaj +1 more source
BRCA1 and BRCA2 founder mutations account for 78% of germline carriers among hereditary breast cancer families in Chile. [PDF]
, 2017 Identifying founder mutations in BRCA1 and BRCA2 in specific populations constitute a valuable opportunity for genetic screening. Several studies from different populations have reported recurrent and/or founder mutations representing a relevant ...
Alvarez, Carolina +12 more
core +2 more sources
Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs
Cancer Science, EarlyView.Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi +2 more
wiley +1 more source
Main risk factors for breast cancer and proposals for its prevention
Опухоли женской репродуктивной системы, 2018 This systematic literature review aims to explore currently accepted risk factors for breast cancer, including reproductive status, overweight, radiation, breast radiological density, benign lesions, family history of breast cancer and mutations in ...
S. M. Portnoy
doaj +1 more source
Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells [PDF]
, 2020 Haohui Duan +11 more
openalex +1 more source
Clinical Genetics, EarlyView.Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu +9 more
wiley +1 more source