Results 171 to 180 of about 68,288 (264)

Ovarian follicular density in women with BRCA1 and BRCA2 mutations: new insights into the negative impact on ovarian reserve. [PDF]

J Ovarian Res
Maletta M, Vicenti R, Forastiere C, Di Santo S, Doglioli M, Lenzi J, Raffone A, Cobellis L, Perandini A, Somigliana E, Seracchioli R, Raimondo D.   +11 more
europepmc   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Breast cancer susceptibility gene 2 upregulation alleviated cardiac hypertrophy in angiotensin II-treated mice. [PDF]

Biochem Biophys Rep
Liu K, Gong XX, Li Y, Li MZ, Si C, Zhou L.   +5 more
europepmc   +1 more source

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source

Cosegregation analysis following an excellent response to olaparib in a pancreatic cancer patient carrier of BRCA2:c.7892 T > C variant enables its reclassification from VUS to pathogenic. [PDF]

BJC Rep
Strojnik K, Blatnik A, Krajc M, Novaković A, Ignjatović M, Ocvirk J, Stegel V, Škerl P, Klančar G, Novaković S, Šetrajčič Dragoš V.   +10 more
europepmc   +1 more source

BRCA2 mutation carriers [PDF]

Nature Genetics, 2013
openaire   +1 more source

Unveiling the Invisible: A Case of Canine Diffuse Microscopic Pancreatic Adenocarcinoma With Normal Imaging and Gross Appearance of the Pancreas Complicated by Sterile Peritonitis and Disseminated Intravascular Coagulation

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
This case report describes an atypical presentation of diffuse microscopic pancreatic adenocarcinoma in an 11‐year‐old male neutered Shetland Sheepdog, which was not detectable on advanced diagnostic imaging or during exploratory laparotomy. Despite the absence of visible pancreatic abnormalities, histopathology confirmed malignant infiltration ...
Hiu Man Chan, Marie‐Laure Théron, Rachel Marwood, Grace P. Lai, Stefan Hobi, Angel Almendros, Antonio Giuliano, Paweł M. Bęczkowski   +7 more
wiley   +1 more source

Linitis Plastica in a Patient With a BRCA2 Mutation: A Case Report. [PDF]

Cureus
Park S, Cao E, Amar S.
europepmc   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, Volume 81, Issue 3, Page 884-901, March 2026.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source

Identification of Genetic Variants Among Breast Cancer Patients and At-Risk Individuals: A Cohort Study in Sri Lanka. [PDF]

Breast Cancer (Auckl)
Yatawara L, Hewavithana B, Ramanayake AP, Wickramasinghe S, Amarasiri M.   +4 more
europepmc   +1 more source