Hyperthermia-induced BRCA2 reduction potentiates PARPi sensitivity in BRCA2-proficient ovarian carcinoma [PDF]
Discover OncologyBackground BRCA2-proficient ovarian cancer (OVCA) exhibits resistance to poly (ADP-ribose) polymerase-1 (PARP) inhibitors (PARPi). This study aims to exploit hyperthermia (HT)-induced BRCA2 reduction as a strategy to enhance OVCA sensitivity to PARPi ...
Bingjie Mei +6 more
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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription [PDF]
Nature CommunicationsGermline monoallelic truncating mutations in BRCA2, a key mediator of homologous recombination (HR), predispose individuals to breast and ovarian cancer.
Anna Minello +19 more
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Identification and Computational Analysis of BRCA2 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer [PDF]
Medical SciencesBackground: Breast and ovarian cancers (BC and OC) are prevalent malignancies in women globally, with germline variants in the BRCA2 gene significantly increasing the risk of developing these cancers.
Patricia Montserrat García-Verdín +16 more
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Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
eLife, 2021 Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection.
Maarten W Paul +7 more
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Parasites & Vectors, 2022 Background Malaria is a major global parasitic disease caused by species of the genus Plasmodium. Zygotes of Plasmodium spp. undergo meiosis and develop into tetraploid ookinetes, which differentiate into oocysts that undergo sporogony.
Yasunaga Yoshikawa +15 more
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Biomolecules, 2021 The maintenance of genome integrity in the cell is an essential process for the accurate transmission of the genetic material. BRCA2 participates in this process at several levels, including DNA repair by homologous recombination, protection of stalled ...
Manon Julien +5 more
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Frontiers in Genetics, 2022 The BRCA2 germline missense variant, R3052W, resides in the DNA binding domain and has been previously classified as a pathogenic allele. In this study, we sought to determine how R3052W alters the cellular functions of BRCA2 in the DNA damage response ...
Judit Jimenez-Sainz +4 more
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BRCA2 c.8827C>T pathogenic mutation in a consanguineous Chinese family with hereditary breast cancer
Molecular Genetics & Genomic Medicine, 2020 Background Mutations in the BRCA2 DNA repair associated gene (BRCA2) are associated with the development of breast cancer, with different ethnic mutations at different sites.
Jiangfen Wang +3 more
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The Could Regulate the Sensitivity of Ovarian Cancer Cells to Platinum-Based Drugs
Technology in Cancer Research & Treatment, 2020 Background and Objective: We have previously reported that BRCA2 N372 H i.a.1342A>C heterozygous variation presented in platinum-resistant patients. This study aimed to further investigate the mechanism of BRCA2 N372 H mutation in the development of ...
Zhen-Hua Du PhD +3 more
doaj +1 more source
A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
Molecular & Cellular Oncology, 2021 In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair ...
Belen Gómez-González +3 more
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