Results 171 to 180 of about 66,967 (213)

Germline <i>BRCA</i> testing in routine clinical practice: a single-center experience. [PDF]

Pathol Oncol Res
Nikolényi A, Dobi Á, Sántha D, Kószó R, Iványi M, Horváth E, Enyedi MZ, Priskin K, Csányi B, Patócs A, Butz H, Papp J, Varga Z, Tóth R, Oláh J, Kahán Z.   +15 more
europepmc   +1 more source

Prevalence of Novel and Recurrent Pathogenic Variants in <i>BRCA</i> Genes in a Cohort of Iranian Hereditary Breast Cancer Patients. [PDF]

Adv Biomed Res
Sarmadi A, Haghjooy Javanmard S, Zeinalian M, Hosseinzadeh M, Tabatabaiefar MA.   +4 more
europepmc   +1 more source

Germline variant spectrum of hereditary cancer susceptibility genes in a Chinese cohort. [PDF]

Hum Genomics
Xiong C, Wang X, Ji J, Yu T, Zhang Y, Jiang Z, Liu J, Zhang J, Lin Y, Gong B, Zhou Y.   +10 more
europepmc   +1 more source

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Suppression of polyploidy by the BRCA2 protein

Cancer Letters, 2007
Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization.
Sagulenko, Evgeny, Savelyeva, Larissa, Ehemann, Volker, Sagulenko, Vitaliya, Hofmann, Wera, Arnold, Katrin, Claas, Andreas, Scherneck, Siegfried, Schwab, Manfred   +8 more
openaire   +3 more sources

Nuclear Localization Signals of the BRCA2 Protein

Biochemical and Biophysical Research Communications, 2000
BRCA2 is a tumor suppressor gene whose germline mutations increase the lifetime risk of breast cancer. BRCA2 encodes a large nuclear protein involved in DNA repair, but the location of its functional domain has been unclear. Here, we report nuclear localization signals (NLSs) of the BRCA2 protein.
K, Yano, K, Morotomi, H, Saito, M, Kato, F, Matsuo, Y, Miki   +5 more
openaire   +2 more sources

Functional Domains of the BRCA1 and BRCA2 Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
The BRCA1 and BRCA2 genes encode large unrelated proteins that presumably function as tumor suppressors in normal epithelial cells of the breast. However, the primary amino acid sequences of these proteins provide few insights into the mechanisms by which BRCA1 and BRCA2 inhibit tumor development.
R, Baer, W H, Lee
openaire   +2 more sources

A kinetoplastid BRCA2 interacts with DNA replication protein CDC45

International Journal for Parasitology, 2009
The gene BRCA2, first identified as a breast cancer susceptibility locus in humans, encodes a protein involved in DNA repair in mammalian cells and mutations in this gene confer increased risk of breast cancer. Here we report a functional characterisation of a Trypanosoma brucei BRCA2 (TbBRCA2) orthologue and show that the protein interacts directly ...
Samuel O, Oyola, Frédéric, Bringaud, Sara E, Melville   +2 more
openaire   +2 more sources