Results 11 to 20 of about 41,270 (209)

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. [PDF]

Cancers (Basel), 2019
The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract therapy-induced DNA damage.
van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R.   +8 more
europepmc   +6 more sources

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2 -Mutated Ovarian Carcinoma [PDF]

Cancer Research, 2009
Abstract Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas. However, the mechanism of the drug resistance has not been elucidated. Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma ...
Sakai, Wataru, Swisher, Elizabeth M, Jacquemont, Céline, Chandramohan, Kurapaty Venkatapoorna, Couch, Fergus J, Langdon, Simon P, Wurz, Kaitlyn, Higgins, Jake, Villegas, Emily, Taniguchi, Toshiyasu   +9 more
openaire   +3 more sources

The BRCA2-Interacting Protein BCCIP Functions in RAD51 and BRCA2 Focus Formation and Homologous Recombinational Repair [PDF]

Molecular and Cellular Biology, 2005
Homologous recombinational repair (HRR) of DNA damage is critical for maintaining genome stability and tumor suppression. RAD51 and BRCA2 colocalization in nuclear foci is a hallmark of HRR. BRCA2 has important roles in RAD51 focus formation and HRR of DNA double-strand breaks (DSBs). We previously reported that BCCIPalpha interacts with BRCA2. We show
Huimei, Lu, Xu, Guo, Xiangbing, Meng, Jingmei, Liu, Chris, Allen, Justin, Wray, Jac A, Nickoloff, Zhiyuan, Shen   +7 more
openaire   +2 more sources

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2 [PDF]

Oncogene, 2003
Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early-onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA double-strand break repair. Both BRCA1 and BRCA2 have also been implicated in transcription by RNA polymerase II, for both proteins have domains which, when ...
Johnson M S, Wong, Daniela, Ionescu, C James, Ingles   +2 more
openaire   +2 more sources

Reduced translation efficiency due to novel splicing variants in 5′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2

BMC Molecular and Cell Biology, 2021
Background Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and downregulation of its expression
Yasunaga Yoshikawa, Hajime Kozuma, Masami Morimatsu, Kaori Sugawara, Koichi Orino   +4 more
doaj   +1 more source

Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas [PDF]

BMC Cancer, 2009
Abstract Background Loss of heterozygosity of chromosome 10q26 has been shown to be associated with the aggressiveness of astrocytic tumors (or astrocytomas), but the responsible gene(s) residing in this region has not been fully identified. The BCCIP gene is located at chromosome 10q26. It encodes a BRCA2 and CDKN1A (
Merlo Adrian, Ohgaki Hiroko, Lu Huimei, Liu Jingmei, Shen Zhiyuan   +4 more
openaire   +3 more sources

Metastatic lung adenocarcinoma with BRCA2 mutation and longstanding disease control on olaparib, developing triple negative breast adenocarcinoma with additional BRCA2 reversion mutation: a case report

Journal of Medical Case Reports, 2023
Background The BRCA2 gene is a well-known tumor suppressor gene implicated in breast and ovarian cancers. BRCA1/2 mutations can be sensitive to poly ADP-ribose polymerase (PARP) inhibitors such as olaparib.
Auro del Giglio, Beatriz da Costa Aguiar Alves, André Márcio Murad, Fernando Luiz Affonso Fonseca   +3 more
doaj   +1 more source

Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism

Frontiers in Oncology, 2022
Mutations in BRCA2 gene increase the risk for breast cancer and for other cancer types, including pancreatic and prostate cancer. Since its first identification as an oncosupressor in 1995, the best-characterized function of BRCA2 is in the repair of DNA
Alessandra Costanza, Nicoletta Guaragnella, Nicoletta Guaragnella, Antonella Bobba, Caterina Manzari, Alberto L’Abbate, Claudio Lo Giudice, Ernesto Picardi, Ernesto Picardi, Anna Maria D’Erchia, Anna Maria D’Erchia, Graziano Pesole, Graziano Pesole, Sergio Giannattasio   +13 more
doaj   +1 more source

Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

Molecular Cancer, 2009
Background DNA repair genes critically regulate the cellular response to chemotherapy and epigenetic regulation of these genes may be influenced by chemotherapy exposure.
Walsh Tom, Garcia Rochelle L, Taniguchi Toshiyasu, Gonzalez Rachel M, Swisher Elizabeth M, Goff Barbara A, Welcsh Piri   +6 more
doaj   +1 more source

The BRC repeats are conserved in mammalian BRCA2 proteins [PDF]

Human Molecular Genetics, 1997
The breast cancer susceptibility gene BRCA2 encodes a protein of 3418 amino acids which does not exhibit substantial sequence similarity to any other protein in the public databases. A dot matrix comparison of BRCA2 with itself revealed an eight times repeated motif in the segment of the protein encoded by exon 11.
G, Bignell, G, Micklem, M R, Stratton, A, Ashworth, R, Wooster   +4 more
openaire   +2 more sources