Results 101 to 110 of about 35,907 (256)

DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers

, 2015
Zsuzsanna Suba Surgical and Molecular Tumor Pathology Centre, National Institute of Oncology, Budapest, Hungary Abstract: Currently available scientific evidence erroneously suggests that mutagenic weakness or loss of the BRCA1/2 genes may liberate the
Suba Z
core  

X chromosome inactivation pattern in BRCA gene mutation carriers.

, 2013
An association of preferential X chromosome inactivation (XCI) with BRCA gene status and breast/ovarian cancer risk has been reported. We evaluated XCI in a large group of BRCA mutation carriers compared to non-carriers and investigated associations ...
P. Colapietro, Allemani, Claudia, J. Burn, S. Manoukian, S. Pizzamiglio, Peissel, Bernard, S.M. Sirchia, F.R. Grati, Manoukian, Siranoush, Radice, Paolo, S. Tabano, Pensotti, Valeria, M. Calvello, Verderio, Paolo, Grati, Francesca R, Calvello, Mariarosaria, M. Miozzo, Sirchia, Silva M, Burn, John, P. Radice, B. Peissel, Colapietro, Patrizia, Miozzo, Monica, V. Pensotti, Pizzamiglio, Sara, P. Verderio, Tabano, Silvia, C. Allemani   +27 more
core   +1 more source

Screening and prevention for inherited cancer: exploring the experiences of BRCA mutation carriers in Newfoundland Labrador

, 2020
Background Females with BRCA 1/2 gene mutations have increased lifetime risk of breast and ovarian cancers. BRCA mutation carriers in NL are not engaging in cancer prevention and screening behaviors according to recommended guidelines.
Hynes, Jaclyn
core   +1 more source

BRCA and early events in the development of high grade serous ovarian cancer

Frontiers in Oncology, 2014
Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer, and epidemiological factors related to parity, ovulation and hormone regulation have a dramatic effect on
Sophia HL George, Patricia eShaw
doaj   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Angelina′s choice

South Asian Journal of Cancer, 2013
This is an opinion piece on how a celebrity′s personal choice to undergo prophylactic mastectomy on discovery of an aberrant gene, when publicly promoted, carries in itself the power to influence and impact healthcare trends and decisions.
Nishu Singh Goel
doaj   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Prediction of Germline BRCA Mutations in High-Risk Breast Cancer Patients Using Machine Learning with Multiparametric Breast MRI Features

Sensors
The identification of germline BRCA1/2 (BRCA) mutations plays an important role in the treatment planning of high-risk breast cancer patients, but genetic testing may be costly or unavailable.
Hyeonji Park, Kyu Ran Cho, SeungJae Lee, Doohyun Cho, Kyong Hwa Park, Yoon Sang Cho, Sung Eun Song   +6 more
doaj   +1 more source

Management of Advanced Prostate Cancer in the Asia‐Pacific Region: Summary of the Asia‐Pacific Advanced Prostate Cancer Symposium 2025

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Summary of the Asia Pacific Advanced Prostate Cancer Symposium 2025, showing disciplines and diversity of participants, discussion topics (high‐risk localized/locally advanced prostate cancer; PSA persistence and recurrence; radioligand therapy; genetics and genomics; bone protection and other aspects of supportive care), key themes, and high‐level ...
Edmund Chiong, Renu Eapen, Nicholas Buchan, Kenneth Chen, Lukman Hakim, Agus Rizal Hamid, Jae‐Young Joung, Ravindran Kanesvaran, Makarand Khochikar, Jason Letran, Bannakij Lojanapiwat, Indranil Mallick, Chi Fai Ng, Pei Ing Ngam, Teng Aik Ong, Jacob Pang, Darren M. C. Poon, Natasha Roberts, Marniza Saad, Shinichi Sakamoto, Jeremy Tey, Sue Ping Thang, Poh Choo Toh, Levent Türkeri, Nguyễn Tuấn Vinh, Alvin Wong, Yao Zhu, ANZUP Cancer Trials Group, Ian D. Davis   +28 more
wiley   +1 more source

The Consequences of a BRCA Mutation in Women [PDF]

Journal of the Advanced Practitioner in Oncology, 2015
Janice, Famorca-Tran, Gayle, Roux
openaire   +2 more sources