Results 101 to 110 of about 33,569 (238)

Angiogenesis‐associated immune genes as prognostic markers and predictors of immunotherapy response in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang, Qian Wang, Xiumei Jiang, Yongmei Yang, Ailin Qu   +4 more
wiley   +1 more source

Efficacy of PARP inhibitors in advanced high-grade serous ovarian cancer according to BRCA domain mutations and mutation type

Frontiers in Oncology
ObjectivePreclinical studies have emphasized the potential connection between BRCA specific domains defects and the activity of Poly ADP-ribose polymerase inhibitors (PARPi).
Roberto Buonaiuto, Roberto Buonaiuto, Giuseppe Neola, Aldo Caltavituro, Aldo Caltavituro, Alessandra Longobardi, Federica Pia Mangiacotti, Amedeo Cefaliello, Maria Rosaria Lamia, Francesco Pepe, Jole Ventriglia, Umberto Malapelle, Giancarlo Troncone, Mario Giuliano, Grazia Arpino, Sandro Pignata, Carmine De Angelis   +16 more
doaj   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Expert consensus on population-based BRCA germline mutation screening in China (2024 edition)

Zhongguo aizheng zazhi
Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can ...
Anti-Cancer Association Tumor Biomarker Professional Committee China, Anti-Cancer Association Tumor Biomarker Professional Committee Shanghai   +1 more
doaj  

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

BRCA Previvors: Medical and Social Factors That Differentiate Them From Previvors With Other Hereditary Cancers

BioéthiqueOnline, 2017
In this paper, I outline some of the reasons why BRCA “previvors” (i.e., “survivors of a predisposition to cancer”) are different from previvors with other hereditary cancers.
Campo-Engelstein, Lisa
doaj  

All‐cause mortality after self‐reported vs. hospital‐reported gynecological surgery: The HUNT study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Mortality risk after hysterectomy and oophorectomy varied between hospital‐reported and self‐reported exposure. This could explain the heterogeneity between previous studies. In this study, hospital‐reported hysterectomy and bilateral oophorectomy were not associated with increased mortality risk, but early bilateral oophorectomy was.
Tina Ellinor Rosland, Nora Johansen, Astrid Helene Liavaag, Bjørn Olav Åsvold, Are Hugo Pripp, Trond Melbye Michelsen   +5 more
wiley   +1 more source

The PSA test for prostate cancer screening: an abridged Cochrane review

BJU International, EarlyView.
Objectives To assess the effects of prostate cancer screening compared to no screening in men with no prior diagnosis of prostate cancer. Methods This systematic review represents an update of a prior Cochrane review from 2013, searching multiple databases up to November 2025. We included randomised controlled trials (RCTs) of prostate cancer screening
Juan V. A. Franco, Eu Chang Hwang, Jae Hung Jung, Octavio Vaimberg, Dragan Ilic, Anne Cleves, Philipp Dahm   +6 more
wiley   +1 more source

Knowledge of BRCA gene among young Pakistani adults: a short report

Journal of the Pakistan Medical Association
A total of 271 young Pakistani adults responded to a self-designed multiple choice-based questionnaire (Alpha = 0.83) which was then used to assess the levels of knowledge regarding breast cancer susceptibility (BRCA) gene mutation.
Shahir Muhammad Ibne Rasa, Daler Ahmad, Mishaal Hasan, Agha Hashim Raza Khan, Minahil Farhan, Farzad Effan   +5 more
doaj   +1 more source

Somatic BRCA Mutation in Metastatic Breast Cancer. [PDF]

Cureus, 2023
Minick TB, Norman RA.
europepmc   +1 more source