Results 81 to 90 of about 33,569 (238)

Prediction of Germline BRCA Mutations in High-Risk Breast Cancer Patients Using Machine Learning with Multiparametric Breast MRI Features

Sensors
The identification of germline BRCA1/2 (BRCA) mutations plays an important role in the treatment planning of high-risk breast cancer patients, but genetic testing may be costly or unavailable.
Hyeonji Park, Kyu Ran Cho, SeungJae Lee, Doohyun Cho, Kyong Hwa Park, Yoon Sang Cho, Sung Eun Song   +6 more
doaj   +1 more source

Is Ductal Carcinoma In Situ a Precursor or Low‐Risk Variant of Invasive Breast Cancer? A Population Perspective

International Journal of Cancer, EarlyView.
ABSTRACT Ductal carcinoma in situ (DCIS) is usually detected with mammography screening and assumed to be a precursor of invasive ductal cancer (IDC) of the breast. Yet, despite an approximately 10‐fold increase in the rate of DCIS detection and treatment within 20 years following implementation of mammography screening in the United States, IDC ...
Ismail Jatoi, Adalberto M. Filho, Gretchen Gierach, Hyuna Sung, Philip S. Rosenberg   +4 more
wiley   +1 more source

APOBEC3A is a prominent cytidine deaminase in breast cancer.

PLoS Genetics, 2019
APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez, Amber L Brown, Madeline A Dennis, Christopher D Collins, Alexander J Brown, Debra Mitchell, Tony M Mertz, Steven A Roberts   +7 more
doaj   +1 more source

The Consequences of a BRCA Mutation in Women [PDF]

Journal of the Advanced Practitioner in Oncology, 2015
Janice, Famorca-Tran, Gayle, Roux
openaire   +2 more sources

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto, Martha Gulati, Suvarna S. Khadilkar, Angela H. E. M. Maas, Federica Frezet, Gláucia Maria Moraes de Oliveira, Andrea R. Genazzani, Hema Divakar, Athena Poppas, on behalf of the World Heart Federation (WHF) and the International Federation of Gynecology and Obstetrics (FIGO)   +9 more
wiley   +1 more source

Occult serous tubal intraepithelial carcinoma and high‐grade serous carcinoma at risk‐reducing salpingo‐oophorectomy in BRCA1/2 carriers: A Czech two‐center cohort

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Risk‐reducing salpingo‐oophorectomy is the standard intervention for prevention of tubo‐ovarian carcinoma in women with pathogenic BRCA1/2 variants, yet the optimal timing remains clinically challenging, particularly for BRCA2 carriers.
Olga Zikan Dubova, Lukas Dostalek, Michal Emingr, Munachiso Ndukwe, Michal Zikan   +4 more
wiley   +1 more source

Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Lynch syndrome and BRCA‐mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer ...
Anna Weimer, Nadeem Abu‐Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y. S. Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting‐Chang Chang, Munanchiso Ndukwe Iheme Jr, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B. Olawaiye   +20 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Carcinoid tumor of lung and BRCA mutation: a case report

Journal of Medical Case Reports, 2019
Background A BRCA mutation is a mutation in either of the BRCA1 or BRCA2 genes, which are tumor suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, whereas ...
Mohammed Z. Shariff, Diana Curras-Martin, Natasha Campbell, Varsha Gupta, John D. Mikhail, Michael J. Levitt, Mohammad A. Hossain   +6 more
doaj   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source