Results 151 to 160 of about 35,907 (256)

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

MedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li, Mingxia Deng, Leqing Zhu, Zhiwei Lei, Rong Guo, Xiong Liu, Renwang Chen, Xichun Xia, Qiong Wen, Yuanyuan Duan, Yan Chen, Zhinan Yin   +11 more
wiley   +1 more source

Generative Artificial Intelligence and Large Language Models in Clinical Oncology

MedComm, Volume 7, Issue 7, July 2026.
By integrating multimodal data, including medical imaging, pathology, omics, and electronic health records, generative AI and LLMs support cancer diagnosis, treatment planning, and follow‐up management. These technologies also enhance physician–patient communication, improve personalized treatment strategies, and leverage intelligent agent automation ...
Yunfang Yu, Zhenhui Zhao, Zehua Wang, Ruichong Lin, Yujie Tan, Yongjian Chen, Ting Li, Daniel Baptista‐Hon, Xiaoxi Zhang, Chuan Wu, Man Tong, Lijun Zheng, Junyan Wu, Olivia Monteiro, Kang Zhang   +14 more
wiley   +1 more source

BRCA mutation testing and association with oncologic outcome and incidence of ovarian cancer in Norway [PDF]

Objective This study aimed to explore the frequency of BRCA mutations and testing, age at diagnosis, and incidence of ovarian cancer and to describe oncologic outcomes in patients carrying BRCA mutation compared with those not carrying mutation, in 1 ...
Paulsen, Torbjørn, Rognlien, Vibeke Wethe, Dørum, Anne, Bjørnslett, Merete Pauline, Myklebust, Tor Åge, Birgisdottir, Alda   +5 more
core   +1 more source

Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications

ChemistryOpen, Volume 15, Issue 7, July 2026.
Magnetic bead engineering for liquid biopsy diagnostics reviews advances in magnetic bead design for the selective enrichment of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) from complex biofluids.
Beatriz Naranjo‐Martínez, Ana Laura Coria‐Gutiérrez, Sunčica Sukur, Sedef Ozel‐Okcu, Václav Ranc, Francisco J. Terán, Franca Raucci, Marco A. Pierotti, Domenico Scionti, Anna Piperno   +9 more
wiley   +1 more source

TONSL Promotes Hepatocellular Carcinoma Progression by Inhibiting Apoptosis Through Homologous Recombination Repair

Cancer Science, Volume 117, Issue 7, Page 1852-1866, July 2026.
In hepatocellular carcinoma, the 8q24.3 locus is frequently amplified and is associated with tumor‐specific overexpression of TONSL. TONSL promotes homologous recombination repair through RAD51, limits γH2AX accumulation and apoptosis, supports tumor growth, and its loss increases sensitivity to poly (ADP‐ribose) polymerase (PARP) inhibition.
Akinori Tsujimoto, Hajime Otsu, Takashi Ofuchi, Tomohiko Ikehara, Kosuke Hirose, Shohei Shibuta, Kazuki Omachi, Yu Takahashi, Yuya Ono, Satoshi Higuchi, Takanari Tatsumi, Kiyotaka Hosoda, Qingjiang Hu, Yusuke Yonemura, Takaaki Masuda, Masayuki Sho, Koshi Mimori   +16 more
wiley   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, Volume 117, Issue 7, Page 1985-1995, July 2026.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab‐paclitaxel

International Journal of Cancer, Volume 158, Issue 12, Page 3091-3100, 15 June 2026.
What's new? Adaptive immune responses are typically limited in pancreatic ductal adenocarcinoma, resulting in minimal efficacy of immune checkpoint inhibitors. Tumor Treating Fields (TTFields) therapy, which uses low‐intensity intermediate‐frequency electric fields to disrupt cancer cell processes, has been approved for certain cancers.
Tal Kan, Tharwat Haj Khalil, Yiftah Barsheshet, Tali Voloshin, Lilach Koren, Bella Koltun, Cfir David, Kerem Wainer‐Katsir, Avital Vorontsova, Boris Brant, Simona Zisman‐Rozen, Hila M. Ene, Roni Frechtel‐Gerzi, Shay Cahal, Anat Klein‐Goldberg, Lena Lifshitz, Efrat Zemer Tov, Mai Shai, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti   +21 more
wiley   +1 more source

A putative role for ALDH inhibitors and chemoprevention of BRCA-mutation-driven tumors. [PDF]

Gynecol Oncol, 2023
McGonigal S, Wu R, Grimley E, Turk EG, Zhai Y, Cho KR, Buckanovich RJ.   +6 more
europepmc   +1 more source

CA125 Levels in BRCA mutation carriers - a retrospective single center cohort study. [PDF]

BMC Cancer, 2023
Gebhart P, Singer CF, Gschwantler-Kaulich D.   +2 more
europepmc   +1 more source