Results 141 to 150 of about 35,907 (256)

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Efficacy of PARP inhibitors in advanced high-grade serous ovarian cancer according to BRCA domain mutations and mutation type

Frontiers in Oncology
ObjectivePreclinical studies have emphasized the potential connection between BRCA specific domains defects and the activity of Poly ADP-ribose polymerase inhibitors (PARPi).
Roberto Buonaiuto, Roberto Buonaiuto, Giuseppe Neola, Aldo Caltavituro, Aldo Caltavituro, Alessandra Longobardi, Federica Pia Mangiacotti, Amedeo Cefaliello, Maria Rosaria Lamia, Francesco Pepe, Jole Ventriglia, Umberto Malapelle, Giancarlo Troncone, Mario Giuliano, Grazia Arpino, Sandro Pignata, Carmine De Angelis   +16 more
doaj   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls.

, 2012
Contains fulltext : 110066.pdf (Publisher’s version ) (Open Access)OBJECTIVE: A precursor lesion for ovarian carcinoma, tubal intraepithelial carcinoma (TIC), has been identified in BRCA-mutation carriers undergoing prophylactic ...
Massuger, L.F.A.G., Mingels, M.J.J.M., Laak, J.A.W.M. van der, Hullu, J.A. de, Ham, M.A.P.C. van, Roelofsen, T., Bulten, J., Bol, M.   +7 more
core   +1 more source

BRCA Previvors: Medical and Social Factors That Differentiate Them From Previvors With Other Hereditary Cancers

BioéthiqueOnline, 2017
In this paper, I outline some of the reasons why BRCA “previvors” (i.e., “survivors of a predisposition to cancer”) are different from previvors with other hereditary cancers.
Campo-Engelstein, Lisa
doaj  

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, Volume 10, Issue 4, Page 1155-1164, July 2026.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source

The follow-up sought after diagnosis of a BRCA-1 or BRCA-2 mutation.

, 2012
57 Background: A woman with a known BRCA mutation has a lifetime risk for the development of breast cancer of up to 80%. Carolinas Medical Center cares for approximately 600 breast cancer patients annually with genetic testing offered to those patients
Terry Sarantou, Wendy Brick, Edward Joey Armstrong, Lisa Amacker-North, Teresa Flippo, Frederick L. Greene, Karinn Marie Chambers, Brook White, Richard L. White   +8 more
core   +1 more source

SDC1 Knockdown Suppresses Malignant Phenotypes of Breast Cancer by Modulating the MAPK Signaling Pathway

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Breast cancer remains a leading cause of morbidity and mortality among women worldwide, necessitating in‐depth research into its molecular mechanisms to improve prognosis and treatment strategies. This study investigates the expression profile and functional role of heparan sulfate proteoglycan Syndecan‐1 (SDC1) in breast cancer progression ...
Weixun Lin, Xiuying Chen, Juan Zou, Yanxian Chen, Zeqi Ji, Zhiyang Li, Bo Xu   +6 more
wiley   +1 more source

Association between BRCA status and T cell-inflamed signature in relation to PTEN mutation status.

, 2019
(A) PTEN protein expression stratified by PTEN copy number alteration and point mutation. (B) Proportion of PTEN mutant samples stratified by BRCA status. (C-E) tSNE visualisation of BRCA1- and BRCA2-deficient breast cancers.
Chee-Onn Leong (3687763), Wei Xiong Wen (5330105)   +1 more
core   +1 more source

Knowledge of BRCA gene among young Pakistani adults: a short report

Journal of the Pakistan Medical Association
A total of 271 young Pakistani adults responded to a self-designed multiple choice-based questionnaire (Alpha = 0.83) which was then used to assess the levels of knowledge regarding breast cancer susceptibility (BRCA) gene mutation.
Shahir Muhammad Ibne Rasa, Daler Ahmad, Mishaal Hasan, Agha Hashim Raza Khan, Minahil Farhan, Farzad Effan   +5 more
doaj   +1 more source