Results 11 to 20 of about 35,907 (256)

Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues.

Hormone Molecular Biology and Clinical Investigation, 2020
Objectives Genetic testing rates for hereditary breast and ovarian cancer (HBOC) have steadily increased during the past decades resulting in a growing population of young and healthy mutation carriers. Available data on fertility issues in BRCA mutation
Siegenthaler, Franziska, Imboden, Sara, Knabben, Laura, Mueller, Michael D.   +3 more
core   +5 more sources

Fertility preservation in patients with BRCA mutation [PDF]

ecancermedicalscience, 2020
Evidence suggests a likely negative impact of deleterious BRCA mutations on female fertility. Hence, different studies have aimed to address the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer ...
Khalife, Dalia, Ghunaim, Suleiman, Azim, Hatem A., Ghazeeri, Ghina S.   +3 more
core   +4 more sources

Management of the asymptomatic BRCA mutation carrier

The Application of Clinical Genetics, 2010
Paige Teller1, Rita K Kramer21Surgical Oncology, 2Medical Oncology, Medical University of South Carolina, Charleston, SC, USAAbstract: Current management of an asymptomatic BRCA mutation carrier includes early initiation and intensive cancer screening in
Paige Teller, Rita K Kramer
core   +6 more sources

Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers [PDF]

BMC Cancer, 2017
Background Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria.
Eli Marie Grindedal, Cecilie Heramb, Inga Karsrud, Sarah Louise Ariansen, Lovise Mæhle, Dag Erik Undlien, Jan Norum, Ellen Schlichting   +7 more
doaj   +2 more sources

Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area

BMC Cancer
Background Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical diversity.
Zhiyuan Wu, Qingyun Zhang, Yiting Jin, Xinju Zhang, Yanli Chen, Can Yang, Xuemei Tang, Haowen Jiang, Xiaoyi Wang, Xinli Zhou, Feng Yu, Bing Wang, Ming Guan   +12 more
doaj   +2 more sources

Somatic BRCA Mutation in a Cholangiocarcinoma Patient for HBOC Syndrome Detection [PDF]

Frontiers in Oncology, 2020
BRCA-associated hereditary breast and ovarian cancer syndrome (HBOC) is characterized by an increased risk of developing other malignancies including cholangiocarcinoma (CCA).
Angelo Virgilio Paradiso, Angelo Virgilio Paradiso, Margherita Patruno, Maria Digennaro, Stefania Tommasi, Brunella Pilato, Antonella Argentiero, Oronzo Brunetti, Nicola Silvestris, Nicola Silvestris   +9 more
doaj   +2 more sources

Somatic BRCA Mutation in High Grade Epithelial Ovarian Cancer Patients

Asian Pacific Journal of Cancer Biology, 2019
Aim: To identify the frequency of somatic BRCA mutation in epithelial ovarian cancer (EOC), particularly those with high grade subtypes. Methods: Patients diagnosed with EOC included fallopian tube cancer or peritoneal cancer who had surgery during ...
Tarinee Manchana, Ruangsak Lertkhachonsuk, Chinachote Teerapakpinyo   +2 more
doaj   +2 more sources

BRCA Mutations and Fertility Preservation [PDF]

International Journal of Molecular Sciences, 2023
Hereditary cancers mostly affect the adolescent and young adult population (AYA) at reproductive age. Mutations in BReast CAncer (BRCA) genes are responsible for the majority of cases of hereditary breast and ovarian cancer. BRCA1 and BRCA2 act as tumor suppressor genes as they are key regulators of DNA repair through homologous recombination. Evidence
Joana Dias Nunes, Isabelle Demeestere, Melody Devos   +2 more
openaire   +2 more sources

BRCA mutations and reproduction [PDF]

Fertility and Sterility, 2018
Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Numerous studies have evaluated the molecular processes involving these genes, the pathophysiology of BRCAness, follow up options and modes of prophylaxis.
Hagit, Daum, Tamar, Peretz, Neri, Laufer
openaire   +2 more sources

Somatic BRCA Mutation in Metastatic Breast Cancer. [PDF]

Cureus, 2023
A 65-year-old female with a history of multicentric invasive ductal breast carcinoma with lobular features and prior mastectomy presented with a chief complaint of two new raised mildly erythematous lesions on the right upper arm. The lesions were visualized during examination, and the patient noted no symptoms associated with them.
Minick TB, Norman RA.
europepmc   +3 more sources