Results 21 to 30 of about 33,569 (238)

Reproductive Issues for Women With BRCA Mutations [PDF]

Journal of the National Cancer Institute Monographs, 2005
Women carrying BRCA1 and BRCA2 mutations face difficult and confusing reproductive decisions that fall into three categories: issues relating to risk-reducing surgeries, issues relating to use of oral contraceptives/tubal ligation, and issues relating to pregnancy and breastfeeding.
Lois C, Friedman, Rita M, Kramer
openaire   +2 more sources

The Study of BRCA1 and BRCA2 Gene Mutations in Benign and Malignant Lesions of the Breast

Sokoto Journal of Medical Laboratory Science, 2023
Understanding the role of BRCA 1 and BRCA2 gene mutations is critical in the study of breast carcinogenesis. The aim was to study was to investigate BRCA | and BRCA2 gene mutations in benign and malignant lesions of the breast.
Ekundina Victor Olukayode , Unuigbokhai Ayomide Olohigbe , Wilson Serbia Princess
doaj  

BRCA mutation in high grade epithelial ovarian cancers

Gynecologic Oncology Reports, 2019
Objective: To identify the frequency of BRCA mutation in patients with high grade epithelial ovarian cancer (EOC). Methods: Patients with EOC included fallopian tube cancer or peritoneal cancer with high grade serous or high grade endometrioid were ...
Tarinee Manchana, Natacha Phoolcharoen, Patou Tantbirojn   +2 more
doaj   +1 more source

MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer

Frontiers in Genetics, 2022
Background: Breast cancer (BRCA) is the most common cancer worldwide and a serious threat to human health. MDN1 mutations have been observed in several cancers.
Shuai Hao, Miao Huang, Xiaofan Xu, Xulin Wang, Liqun Huo, Lu Wang, Jun Gu   +6 more
doaj   +1 more source

Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma

BMC Cancer, 2019
Background High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP ...
Andreja Gornjec, Srdjan Novakovic, Vida Stegel, Marko Hocevar, Ziva Pohar Marinsek, Barbara Gazic, Mateja Krajc, Erik Skof   +7 more
doaj   +1 more source

Endometrial Cancer and BRCA Mutations: A Systematic Review

Journal of Clinical Medicine, 2022
This systematic review identifies, evaluates, and summarises the findings of all relevant individual studies on the prevalence of BRCA mutation (BRCAm) in endometrial cancer patients and the incidence of endometrial cancer in BRCAm women patients. Consequently, the benefits and limits of a prophylactic hysterectomy at the time of the risk-reducing ...
Maria Gasparri, Serena Bellaminutti, Ammad Farooqi, Ilaria Cuccu, Violante Di Donato, Andrea Papadia   +5 more
openaire   +3 more sources

Subtypes in BRCA-mutated breast cancer [PDF]

Human Pathology, 2019
Summary Approximately 3% to 5% of breast cancer patients are BRCA1 or BRCA2 germline mutation carriers. In this study, we correlated the distribution of intrinsic molecular subtypes according to failure pattern in a Danish cohort of BRCA germline–mutated breast cancer patients.
Sønderstrup, Ida Marie H, Jensen, Maj-Britt R, Ejlertsen, Bent, Eriksen, Jens O, Gerdes, Anne-Marie, Kruse, Torben A, Larsen, Martin J, Thomassen, Mads, Lænkholm, Anne-Vibeke   +8 more
openaire   +4 more sources

Detection of BRCA1, and BRCA2 Alterations in Matched Tumor Tissue and Circulating Cell-Free DNA in Patients with Prostate Cancer in a Real-World Setting

Biomedicines, 2022
Background: Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for patients with metastatic castration-resistant prostate cancer harboring deleterious or suspected deleterious BRCA1 and/or 2 mutations.
Taylor Ryan McFarland, Vinay Mathew Thomas, Roberto Nussenzveig, Georges Gebrael, Nicolas Sayegh, Nishita Tripathi, Kamal Kant Sahu, Divyam Goel, Benjamin L. Maughan, Deepika Sirohi, Neeraj Agarwal, Umang Swami   +11 more
doaj   +1 more source

The association between non-breast and ovary cancers and BRCA mutation in first- and second-degree relatives of high-risk breast cancer patients: a large-scale study of Koreans

Hereditary Cancer in Clinical Practice, 2019
Background As a large-scale study of Koreans, we evaluated the association between BRCA mutation and the prevalence of non-breast and ovary cancers in first- and second-degree relatives of high-risk breast cancer patients.
Hakyoung Kim, Doo Ho Choi, Won Park, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong Hwan Yu, Se Kyung Lee, Boo Yeon Jung   +11 more
doaj   +1 more source

Potential Association of BRCA Mutation and Lymphocytic Lobulitis. [PDF]

Clin Case Rep
ABSTRACT Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long‐standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed
Garg P, Park S, Ayeni FE, Edirimanne S.
europepmc   +2 more sources