Results 31 to 40 of about 35,907 (256)

MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer

open access: yesFrontiers in Genetics, 2022
Background: Breast cancer (BRCA) is the most common cancer worldwide and a serious threat to human health. MDN1 mutations have been observed in several cancers.
Shuai Hao   +6 more
doaj   +1 more source

Reproductive Issues for Women With BRCA Mutations [PDF]

open access: yesJournal of the National Cancer Institute Monographs, 2005
Women carrying BRCA1 and BRCA2 mutations face difficult and confusing reproductive decisions that fall into three categories: issues relating to risk-reducing surgeries, issues relating to use of oral contraceptives/tubal ligation, and issues relating to pregnancy and breastfeeding.
Lois C, Friedman, Rita M, Kramer
openaire   +2 more sources

BRCA mutation in high grade epithelial ovarian cancers

open access: yesGynecologic Oncology Reports, 2019
Objective: To identify the frequency of BRCA mutation in patients with high grade epithelial ovarian cancer (EOC). Methods: Patients with EOC included fallopian tube cancer or peritoneal cancer with high grade serous or high grade endometrioid were ...
Tarinee Manchana   +2 more
doaj   +1 more source

Survival and Chemosensitivity in Advanced High Grade Serous Epithelial Ovarian Cancer Patients with and without a BRCA Germline Mutation: More Evidence for Shifting the Paradigm towards Complete Surgical Cytoreduction

open access: yesMedicina, 2022
Background and Objectives: Approximately 10–15% of high-grade serous ovarian cancer (HGSOC) cases are related to BRCA germline mutations. Better survival rates and increased chemosensitivity are reported in patients with a BRCA 1/2 germline mutation ...
Diederick De Jong   +8 more
doaj   +1 more source

Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location

open access: yes, 2021
Hereditary breast and ovarian cancer is caused by a germline mutation in BRCA1 or BRCA2 genes. The frequency of germline BRCA1/2 gene mutation carriers and the ratio of germline BRCA1 to BRCA2 mutations in BRCA-related cancer patients vary depending on ...
Koji Nishino   +2 more
core   +1 more source

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +1 more source

Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma

open access: yesBMC Cancer, 2019
Background High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP ...
Andreja Gornjec   +7 more
doaj   +1 more source

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells [PDF]

open access: yes, 2010
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this ...
Valeri, Antonio   +71 more
core   +1 more source

Subtypes in BRCA-mutated breast cancer [PDF]

open access: yesHuman Pathology, 2019
Summary Approximately 3% to 5% of breast cancer patients are BRCA1 or BRCA2 germline mutation carriers. In this study, we correlated the distribution of intrinsic molecular subtypes according to failure pattern in a Danish cohort of BRCA germline–mutated breast cancer patients.
Sønderstrup, Ida Marie H   +8 more
openaire   +4 more sources

Dermatological and Dermoscopic Baselines in BRCA Mutation Carriers. [PDF]

open access: yesFront Med (Lausanne), 2022
Breast cancer-associated genes 1 and 2 (BRCA1 and BRCA2) are tumor suppressor genes encoding a large protein that is involved in many essential biological processes. BRCA mutated patients show an increased risk to develop several malignancies, including cutaneous malignancies, although inconsistently across multiple studies.
Paolino G   +7 more
europepmc   +6 more sources

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