Results 31 to 40 of about 54,591 (139)

SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]

, 2015
Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa, Marchal, Kathleen, Van den Eynden, Jimmy, Verbeke, Lieven   +3 more
core   +2 more sources

No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers

Breast Cancer Research and Treatment, 2007
Q2 ; Q1 ; Editorial ; 155-156 ; To the editorAbout 5% of breast cancers and 10% of ovariancancers are a result of germ line mutations in theBRCA1(MIM 113705) andBRCA2(MIM 600185)genes [1,2].
Muhammad U, Rashid, Diana, Torres, Anbreen, Zaidi, Farah, Rasheed, Faisal, Sultan, Abdul R, Shakoori, Asim, Amin, Ute, Hamann   +7 more
openaire   +3 more sources

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]

, 2018
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico, Andrew D, Cherniack, Bin, Feng, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Casey S, Greene, Chase, Miller, Chen, Wang, Christina, Yau, David A, Wheeler, Denise, Wolf, Eve, Shinbrot, Galen F, Gao, Gaudio, Eugenio, Gordon B, Mills, Gregory P, Way, Hai, Hu, Haoran, Chen, Hui, Shen, Huihui, Fan, Ilya, Shmulevich, Jianfang, Liu, John N, Weinstein, Lawrence A, Donehower, Lei, Li, Li, Ding, Linghua, Wang, Matthew H, Bailey, Michael T, Zimmermann, Mostafa, Karimi, Nyasha, Chambwe, Peilin, Jia, Peter W, Laird, Pora, Kim, Raymond J, Monnat, Rehan, Akbani, Shaojun, Zhang, Theo A, Knijnenburg, Yang, Shen, Yonghong, Xiao, Yuexin, Liu, Zhongming, Zhao   +41 more
core   +1 more source

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources

Functional consequence of the MET-T1010I polymorphism in breast cancer. [PDF]

, 2014
Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk.
Brown, Powel H, Chavez-MacGregor, Mariana, Chen, Ken, Eterovic, Agda K, Gagea, Mihai, Gonzalez-Angulo, Ana M, Hortobagyi, Gabriel N, Lei, Xiudong, Liu, Shuying, Mendelsohn, John, Meric-Bernstam, Funda, Mills, Gordon B, Nair, Lakshmy, Parinyanitikul, Napa, Tripathy, Debu, Ueno, Naoto T, Wang, Bailiang, Zheng, Xiaofeng, Zhou, Wanding   +18 more
core   +2 more sources

Niraparib in ovarian cancer. results to date and clinical potential [PDF]

, 2017
Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both ...
Benedetti Panici, Pierluigi, Caruso, Davide, Papa, Anselmo, Tomao, Federica, Tomao, Silverio, Vici, Patrizia   +5 more
core   +1 more source

A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core   +1 more source

Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers [PDF]

, 2009
Background. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.
Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti, Antonella Savarese, H Chaliki, RT Croyle, K Brain, C Lerman, KM Kash, M Watson, I Van Oostrom, AR Bradbury, G Rees, KJ Schlich-Bakker, K Kelly, KM Kelly, L D'Agincourt-Canning, MC Katapodi, MB Daly, FM Walter, JM Quillin, F Gil, A Caruso, DA Berry, G Parmigiani, M Federico, L Cortesi, A Caruso, A Caruso, C Lerman, D Ehus, DA Berry, TS Frank, FJ Couch, AS Zigmond, M Costantini, LG Bluman, J Cohen, JR Landis, C Foster, B Meiser, DG Evans, JT Heshka, C Condello, C Lerman   +47 more
core   +3 more sources

Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]

, 2014
Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core   +5 more sources

Reproductive Issues for Women With BRCA Mutations [PDF]

Journal of the National Cancer Institute Monographs, 2005
Women carrying BRCA1 and BRCA2 mutations face difficult and confusing reproductive decisions that fall into three categories: issues relating to risk-reducing surgeries, issues relating to use of oral contraceptives/tubal ligation, and issues relating to pregnancy and breastfeeding.
Lois C, Friedman, Rita M, Kramer
openaire   +2 more sources