Results 111 to 120 of about 26,367 (213)

Research Progress on Pathogenesis and Treatment of NUT Carcinoma

Chinese Journal of Lung Cancer
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family ...
Jiaxin DU, Xinwei ZHANG
doaj   +1 more source

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching [PDF]

, 2014
BACKGROUND: Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of ...
Anne-Claude Gingras, Catherine M Rogers, Chris Wells, Claire Strain-Damerell, Clarence Yapp, Jean-Philippe Lambert, Martin Philpott, Nicola A Burgess-Brown, Stefan Knapp, Susanne Müller   +9 more
core   +2 more sources

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer [PDF]

, 2014
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in several models of cancer have not been evaluated in TNBC.
Anders, Lars, Barry, William T., Bradner, James, Brown, Jonathan, Brown, Myles, Carroll, Jason S., Chiang, Cheng-Ming, Dillon, Deborah, Doherty, Ernest, Duarte, Melissa, D’Santos, Clive, Ekram, Muhammad B., Guo, Hao, He, Housheng Hansen, Janiszewska, Michalina, Jin Huh, Sung, Krop, Ian E., Letai, Antony, Liang, Yi, Lin, Charles Y., Liu, X. Shirley, Long, Henry W., McKeown, Michael, Meyer, Clifford A., Mohammed, Hisham, Ni, Min, Ott, Christopher, Peluffo, Guillermo, Polyak, Kornelia, Qi, Jun, Rao, Prakash K., Roberts, Justin M., Ryan, Jeremy, Shu, Shaokun, Stover, Daniel G., Tabassum, Doris P., Winer, Eric P., Witwicki, Robert M., Wu, Shwu-Yuan, Young, Richard A.   +39 more
core   +1 more source

Structural maintenance of chromosome protein 1A exacerbates liver fibrosis by enhancing hepatic stellate cell activation and extracellular matrix synthesis via laminin subunit gamma 2 activation

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Structural maintenance of chromosome protein 1A activates the PI3K/Akt signaling pathway by promoting laminin subunit gamma 2 transcription, which facilitates hepatic stellate cell activation and extracellular matrix deposition, leading to liver fibrosis progression.
Dandan Wang, Ning Li, Ranyan Gao, Jiaxin Wang, Lingyi Xu, Fengchun Li, Xinyu Geng, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, Xiaoyu Zhang, Shuang Jin, Shizhu Jin   +11 more
wiley   +1 more source

Study of P-TEFb reconstitution [PDF]

, 2016
P-TEFb在基因转录调控中具有重要地位。因此围绕P-TEFb的研究是基因转录调控研究中的重点问题。为了适应转录本身的复杂性，P-TEFb的活性调控以及其募集的方式也非常精致复杂。本文详细揭示了具有调控转录活性的，活化态P-TEFb的形成过程，即P-TEFb的重活化。 之前我们发现激酶活性受到限制的P-TEFb存在于核浆中的7SKsnRNP复合物中。在细胞受到外界刺激（如HMBA）时可以从7SKsnRNP中解离而最终产生活化态的P-TEFb。这个过程伴随着CDK9-T186位的去磷酸化 ...
李游
core  

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Brd4-P-TEFb and SECs complexs cooperatively regulate RNA Pol II pause release via different recruitment pathways [PDF]

, 2015
真核基因转录调控是细胞基因表达调控网络的基础，细胞内编码蛋白的基因和核内小RNA（snRNA）的转录是由RNA聚合酶II（RNAPolII）负责的。RNAPolII控制的转录由前起始复合物组装、转录起始、启动子清理、转录延伸、转录终止等5步依次协同完成。正性转录延伸因子b（P-TEFb）发现之前，研究人员一直认为转录前起始复合物组装和转录起始是转录调控的关键步骤。随着人们对P-TEFb在转录调控方面研究的深入，发现转录延伸同样受到严密及精细的调控，是基因转录的限速步骤。 最近的研究表明 ...
陆小冬
core  

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition [PDF]

, 2018
Allele-specific chemical genetics enables selective inhibition within families of highly-conserved proteins. The four BET (bromodomain & extra-terminal domain) proteins – BRD2, BRD3, BRD4 and BRDT bind acetylated chromatin via their bromodomains and ...
Albrecht, Amorim, Anders, Andrieu, Arrowsmith, Bamborough, Bamborough, Baud, Baud, Bishop, Bolden, Bunnage, Cheung, Clackson, Conery, Dawson, Deeney, Delmore, Dubocovich, Filippakopoulos, Filippakopoulos, Gacias, Gadd, Galdeano, Gamsjaeger, Huang, Islam, Lamonica, Li, Lin, Lu, Miller, Mirguet, Muller, Nassar, Nguyen, Nicholls, Nicodeme, Philpott, Picaud, Raina, Raux, Runcie, Sander, Schroder, Shi, Shi, Smith, Stathis, Stonestrom, Tanaka, Theodoulou, Theodoulou, Wang, Winter, Yang, Zengerle, Zhou, Zou, Zuber   +59 more
core   +2 more sources

Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis

International Journal of COPD, 2021
Caifen Zheng,1 Yongping Zhang,2 Yingchun Zhao,3 Yuanfang Duan,1 Qianghua Mu,1 Xinying Wang1 1Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Lianyungang, Lianyungang, People’s Republic of China; 2Blood ...
Zheng C, Zhang Y, Zhao Y, Duan Y, Mu Q, Wang X   +5 more
doaj