Results 131 to 140 of about 26,367 (213)
Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao +5 more
wiley +1 more source
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Cell GenomicsSummary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number.
Jeremiah Wala +8 more
doaj +1 more source
PLoS ONE, 2012 Some anti-cancer drugs, including those that alter microtubule dynamics target mitotic cells and induce apoptosis in some cell types. However, such drugs elicit protective responses in other cell types allowing cells to escape from drug-induced mitotic ...
Akira Nishiyama +4 more
doaj +1 more source
Activation of Latent HIV-1 by Marine Shellfish Toxins [PDF]
, 2016 高效抗逆转录病毒疗法（HAART）是目前治疗艾滋病最可靠的方法，HAART可以通过药物联用的方法有效的降低艾滋病感染者的死亡率，但由于HIV的潜伏感染，HAATR疗法并不能将HIV病毒从体内完全清除，患者体内的HIV病毒潜伏库是彻底治愈艾滋病的巨大挑战。随着“ShockandKill”的治疗新策略的提出，通过激活潜伏期HIV病毒库进而根除潜伏病毒，从而实现艾滋病的彻底根治。因此寻找高效低毒HIV潜伏激活剂具有重要的科学意义和应用价值。 本研究基于J ...
余雕
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MiR-218 Inhibits CSE-Induced Apoptosis and Inflammation in BEAS-2B by Targeting BRD4
International Journal of COPD, 2020 Xiaoli Liu,1 Junchen Wang,2,3 Huiling Luo,1 Chengxu Xu,1 Xingyu Chen,1 Rongxuan Zhang1 1Department of Respiratory, The Second People’s Hospital of Lanzhou City, Lanzhou City, Gansu Province, People’s Republic of China; 2Department of ...
Liu X +5 more
doaj
Blue‐Gray Papules on the Chest and Face
JEADV Clinical Practice, Volume 5, Issue 1, Page 326-329, March 2026.
Sanjana Likki +5 more
wiley +1 more source
Dihydropteridinone Inhibitors of BRD4 [PDF]
ACS Medicinal Chemistry Letters, 2015 openaire +2 more sources
An updated patent review of BRD4 degraders
Expert Opinion on Therapeutic PatentsBromodomain-containing protein 4 (BRD4), an important epigenetic reader, is closely associated with the pathogenesis and development of many diseases, including various cancers, inflammation, and infectious diseases. Targeting BRD4 inhibition or protein elimination with small molecules represents a promising therapeutic strategy, particularly for ...
Zonghui Ma +3 more
openaire +2 more sources
BRD4: an effective target for organ fibrosis
Biomarker ResearchAbstractFibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis is reported to cause 45% of all-cause mortality worldwide. Despite extensive efforts to develop new antifibrotic drugs, drug discovery has
Qun Wei +8 more
openaire +3 more sources
Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut
CellsExperimental evidence suggests that, in the inflamed gut of inflammatory bowel disease (IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways.
Eleonora Franzè +6 more
doaj +1 more source