Results 31 to 40 of about 26,367 (213)
Unveiling the folding mechanism of the bromodomains [PDF]
, 2017 Bromodomains (BRDs) are small protein domains often present in large multidomain proteins involved in transcriptional regulation in eukaryotic cells. They currently represent valuable targets for the development of inhibitors of aberrant transcriptional ...
Bonetti, Daniela +6 more
core +2 more sources
A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia [PDF]
, 2018 MYC-translocated T-lineage acute lymphoblastic leukemia (T-ALL) is a rare subgroup of T-ALL associated with CDKN2A/B deletions, PTEN inactivation, and absence of NOTCH1 or FBXW7 mutations.
Amadori, Alberto +12 more
core +2 more sources
BRD4 (bromodomain containing 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +1 more source
Scientific Reports, 2017 The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-TEFb.
Tim-Michael Decker +6 more
doaj +1 more source
Expression and purification of an NSD3-GB1 fusion protein as a way to study the structure of complex formation with Brd4 ET. [PDF]
, 2020 The BRD4 protein belongs to the bromodomain and extraterminal domain (BET) family of eukaryotic transcription factors, and is linked to several types of cancer, inflammation, and obesity.
Tuokkola, Jennifer
core
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains [PDF]
, 2018 Bromodomains have been pursued intensively over the past several years as emerging targets for the development of anticancer and anti-inflammatory agents.
Alessi, Dario R. +27 more
core +3 more sources
Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
Cancer Cell International, 2020 Background The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, and are essential for cell survival and also are promising anticancer targets.
Feng Jiao +6 more
doaj +1 more source
Transcription, 2013 The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.
Ballachanda N, Devaiah, Dinah S, Singer
openaire +2 more sources
Frontiers in Medicine, 2020 Objectives: This study aimed to explore the relationship between bromodomain-containing protein 4 (BRD4), epithelial–mesenchymal transition (EMT), and disease severity in chronic rhinosinusitis with nasal polyps (CRSwNP).Methods: We performed ...
Xuanchen Zhou +10 more
doaj +1 more source
BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange–like syndrome [PDF]
Nature Genetics, 2018 We found that the clinical phenotype associated with BRD4 haploinsufficiency overlapped with that of Cornelia de Lange syndrome (CdLS), which is most often caused by mutation of NIPBL. More typical CdLS was observed with a de novo BRD4 missense variant, which retained the ability to coimmunoprecipitate with NIPBL, but bound poorly to acetylated ...
Olley, Gabrielle +15 more
openaire +5 more sources