Results 41 to 50 of about 26,367 (213)

Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct

Scientific Reports, 2023
Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives changes in gene expression in Nut Carcinoma. Here we sought to understand the molecular
Martyna Kosno, Simon L. Currie, Ashwani Kumar, Chao Xing, Michael K. Rosen   +4 more
doaj   +1 more source

Molecular Dynamic Simulations of Bromodomain and Extra-Terminal Protein 4 Bonded to Potent Inhibitors

Molecules, 2021
Bromodomain and extra-terminal domain (BET) subfamily is the most studied subfamily of bromodomain-containing proteins (BCPs) family which can modulate acetylation signal transduction and produce diverse physiological functions.
Siao Chen, Yi He, Yajiao Geng, Zhi Wang, Lu Han, Weiwei Han   +5 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
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Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Mechanisms of YAP/TAZ transcriptional control

Cell Stress, 2021
Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor ...
Giusy Battilana, Francesca Zanconato, Stefano Piccolo   +2 more
doaj   +1 more source

BRD4 and Cancer: going beyond transcriptional regulation [PDF]

Molecular Cancer, 2018
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-specific repression of oncogenes to which cancer cells ...
Benedetta Donati, Eugenia Lorenzini, Alessia Ciarrocchi   +2 more
openaire   +3 more sources

Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Molecular & Cellular Oncology, 2019
The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial ...
Gianluca Civenni, Giuseppina M. Carbone, Carlo V. Catapano   +2 more
doaj   +1 more source

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
A Barski, A Barski, A Morotti, AJ Donner, An-Jey A. Su, AR Brasier, B Grondin, BL Ebert, BN Devaiah, C Hagemeier, C Jiang, C-Y Chen, CA Dinarello, CA Dinarello, Chunhong Yan, CK Lee, DA Gilchrist, DA Gilchrist, DC Hargreaves, DE Schones, Deborah L. Galson, DJ Van Antwerp, DL Galson, DV Kuprash, E Kowenz-Leutz, F Sandor, F Shirakawa, F Shirakawa, G Natoli, Gillian M. Tannahill, GM Tannahill, GM Tannahill, GW Muse, HT Kang, J Dekker, J Dekker, J Hiscott, J Tsukada, J Tsukada, J Xie, JA Listman, JM Argiles, Juraj Adamik, K Adelman, Kent Z. Q. Wang, KJ Meaburn, KZ Wang, L Bai, L Escoubet-Lozach, LJ Core, Luke A. O’Neill, M Kronke, M Vermeulen, MA Collart, MG Guenther, MJ Fenton, MO Hottiger, N Wara-aswapati, NS Kenneth, PE Auron, Philip E. Auron, Q Zhou, RC Akkers, S Egloff, S Ghisletti, S Heinz, S Henikoff, S Marecki, S Marmiroli, S Mink, S Unlu, SA Godambe, Sebnem Unlu, SH Zuckerman, SJ Petesch, SK Roy, SL Foster, SN Sarkar, SP Davies, T Lawrence, T Mitchell, T Tando, TN Mavrich, W Deng, X Contreras, Y Kominato, Y Yoshida, Z Yang, Z Yang   +88 more
core   +3 more sources

CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis

International Journal of COPD, 2021
Zheng Wang,1 Yuqiang Zuo,2 Zhihong Gao2 1Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of Physical Examination Center, The Second Hospital ...
Wang Z, Zuo Y, Gao Z
doaj  

DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

Frontiers in Molecular Biosciences, 2020
The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 mediates the recruitment of active P-TEFb to the promoter,
Yawei Song, Yawei Song, Yawei Song, Yawei Song, Yawei Song, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Jinping Jia, Mingze Yao, Xiaoshan Wang, Wenliang Lu, Andrew P. Hutchins, Jiekai Chen, Jiekai Chen, Jiekai Chen, Keiko Ozato, Hongjie Yao, Hongjie Yao, Hongjie Yao, Hongjie Yao   +21 more
doaj   +1 more source