Results 161 to 170 of about 131,173 (232)

LAP2α drives breast tumorigenesis by mitigating replication stress. [PDF]

Cell Death Dis
Ma Y, Qin Y, Bao P, Wei A, Yang Z, Liu L, Liu S, Foisner R, Shi L, Zhang Q, Bao K.   +10 more
europepmc   +1 more source

Synthetic Multidomain Proteins Containing Unstructured and α‑Helical Linkers Reveal a Differential Impact of Molecular Crowding on Catalytic Activity and Conformation. [PDF]

ACS Omega
Sultana A, Geethakumari AM, Ahmed WS, Biswas KH.   +3 more
europepmc   +1 more source

Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. [PDF]

Comput Struct Biotechnol J
Wimmer T, Schneider J, Alabudeeb F, Türk FM, Lytvynchuk L, Stieger K.   +5 more
europepmc   +1 more source

GPCR kinase 3 phosphorylates atypical chemokine receptor 4 independent of G proteins

Lamme TD, Sánchez Arroyo IB, Smit MJ, Schafer CT.   +3 more
europepmc   +1 more source

Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

de Boer B, Lamme TD, Verdwaald K, Medina SS, Németh CG, Elfrink EM, Smit MJ, de Esch IJ, Schafer CT.   +8 more
europepmc   +1 more source

DELs enable the development of BRET probes for target engagement studies in cells

Cell Chemical Biology, 2023
DNA-encoded libraries (DELs) provide unmatched chemical diversity and starting points for novel drug modalities. Here, we describe a workflow that exploits the bifunctional attributes of DEL ligands as a platform to generate BRET probes for live cell ...
Mei Cong, Cesear R Corona
exaly   +2 more sources

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

International Journal of Molecular Sciences, 2022
Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The modulation of cGMP is important in many diseases, but reliably assaying cGMP in live cells in a plate-based format with ...
Ross Bathgate, Daniel Scott, Sarah Arwen Marshall   +2 more
exaly   +2 more sources

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HER2-specific liposomes loaded with proteinaceous BRET pair as a promising tool for targeted self-excited photodynamic therapy.

European journal of pharmaceutics and biopharmaceutics, 2023
Photodynamic therapy (PDT) for deep-seated tumors is still challenging due to the limited penetration of visible light through tissues. To resolve this limitation, systems based on bioluminescence resonance energy transfer (BRET), that do not require an ...
E. Shramova, V. P. Filimonova, A. Frolova, E. B. Pichkur, Vlad R Fedotov, A. L. Konevega, S. Deyev, G. Proshkina   +7 more
semanticscholar   +1 more source

BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations

International Journal of Molecular Sciences, 2021
G-protein-coupled receptors (GPCRs) are dimeric proteins, but the functional consequences of the process are still debated. Active GPCR conformations are promoted either by agonists or constitutive activity.
Severine Morisset, Severine Morisset-Lopez   +1 more
exaly   +2 more sources