Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study [PDF]
Drug Delivery, 2019 Brimonidine tartrate (BRT) is a hydrophilic α2 adrenergic agonist used for the treatment of glaucoma. Glaucoma is an ocular disease affecting the anterior segment of the eye requiring lifetime treatment.
Alaa Emad Eldeeb +2 more
doaj +4 more sources
Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes [PDF]
International Journal of Nanomedicine, 2022 Engy A Abdel Azim,1 Seham A Elkheshen,2,* Rania M Hathout,3,* Marwa A Fouly,4 Nada M El Hoffy1 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Future University in Egypt, New Cairo, Cairo, 11835, Egypt ...
Abdel Azim EA +4 more
doaj +4 more sources
Brimonidine tartrate 0.15% drops to reduce low post-LASIK residual myopia: A retrospective study. [PDF]
PLoS ONEPurposeResidual myopia following Laser-assisted in situ keratomileusis (LASIK) surgery poses a significant concern, with existing literature extensively detailing the use of timolol for treatment.
Nir Gomel +11 more
doaj +4 more sources
Comparisons of efficacy and safety between preserved and preservative-free brimonidine tartrate in glaucoma and ocular hypertension: a parallel-grouped, randomized trial [PDF]
Scientific Reports, 2023 This multicenter (four institutions), randomized, investigator-masked, parallel-group clinical trial evaluated and compared the efficacy and safety of preservative-free and preserved brimonidine tartrate 0.15% in open-angle glaucoma and ocular ...
Ko Eun Kim +4 more
doaj +2 more sources
A novel reversed phase high performance liquid chromatography approach for stability-indicating simultaneous analysis of brimonidine tartrate and timolol maleate [PDF]
Frontiers in ChemistryIntroductionThe simultaneous quantification of Brimonidine Tartrate and Timolol Maleate in ophthalmic formulations is essential for ensuring product quality, efficacy, and stability.
Aktham Mestareehi, Aktham Mestareehi
doaj +2 more sources
Preparation and Characterization of Ion-Sensitive Brimonidine Tartrate In Situ Gel for Ocular Delivery [PDF]
Pharmaceuticals, 2023 Brimonidine tartrate (BRT) is a highly selective α2 adrenergic receptor agonist as treatment for patients with open angle glaucoma and high intraocular pressure.
Haonan Xu +6 more
doaj +2 more sources
Comparative efficacy study of brimonidine tartrate 0.15% and timolol maleate 0.5% ophthalmic solution (benzalkonium chloride free) versus Brimolol® (with benzalkonium chloride) following single ocular instillation in New Zealand white rabbits [PDF]
, 2020 Background: Benzalkonium chloride (BKC) is the most used preservative in topical eye drops but it causes effects such as dry eye and trabecular meshwork degeneration.
Bhowmick, Subhas +3 more
core +3 more sources
A validated stability-indicating HPLC method for determination of brimonidine tartrate in BRI/PHEMA drug delivery systems [PDF]
Chemistry Central Journal, 2017 Background A simple, rapid and accurate stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) was developed and validated for the determination of brimonidine tartrate in brimonidine tartrate/poly(2-hydroxyethyl methacrylate)
Jianguo Sun, Xiuwen Zhang, Taomin Huang
doaj +2 more sources
Use of brimonidine tartrate to resolve telangiectatic matting: case report. [PDF]
J Vasc Bras, 2020 Sclerotherapy is currently the treatment of choice for telangiectasias and reticular veins, with grade 1A recommendation in the European Guideline for sclerotherapy. The most common side effects of this procedure are hyperpigmentation and telangiectatic matting, the second of which provokes great concern because of the esthetic damage and the ...
de Mello BAS +5 more
europepmc +3 more sources
Clinical efficacy and neuroprotective effects of brimonidine in the management of glaucoma and ocular hypertension [PDF]
Clinical Ophthalmology, 2008 Anna Galanopoulos1, Ivan Goldberg21Senior Visiting Ophthalmologist, South Australian Institute of Ophthalmology and Dept of Ophthalmology and Visual Sciences, University of Adelaide, South Australia; 2Clinical Associate Professor, University of Sydney ...
Anna Galanopoulos, Ivan Goldberg
doaj +5 more sources