Nanovesicular Formulation of Brimonidine Tartrate for the Management of Glaucoma: In Vitro and In Vivo Evaluation [PDF]
In this study, nanovesicles were developed for brimonidine tartrate by film hydration technique and dispersed in viscous carbopol solution for ocular delivery. Scanning electron microscopy revealed spherical shape of the vesicles. As high as 32.27% drug entrapment efficiency was achieved depending upon the surfactant/cholesterol molar ratio (7:4 to 7:8)
Sabyasachi Maiti+4 more
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Modification of contact lenses via metal‐organic frameworks for glaucoma treatment
The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal‐organic frameworks with sustained release of brimonidine for prolonged glaucoma ...
Alexey V. Yaremenko+21 more
doaj +2 more sources
Fluorimetric quantification of brimonidine tartrate in eye drops.
A simple and sensitive spectrofluorimetric method has been developed for the estimation of brimonidine tartrate in pure and eye drops. Linearity was obeyed in the range of 0.2-3.0 ΅g/ml in dimethyl formamide as solvent at an emission wavelength (λem) of 530 nm after excitation wavelength (λex) of 389 nm with good correlation coefficient of 0.998.
Sunitha G+5 more
europepmc +4 more sources
Charles Bonnet syndrome precipitated by brimonidine tartrate eye drops [PDF]
Brimonidine tartrate (BT) (Alphagan) is an α-2 adrenergic agonist marketed for treatment of primary open angle glaucoma (POAG) which may have neuroprotective effects.1 One report of acute delusional psychosis with auditory hallucinations in a 68 year old man treated for POAG has been published,2 and use of BT eye drops in an infant resulted in coma and
Robert L. Tomsak
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Development and validation of spectrophotometric methods for the simultaneous determination of Brimonidine Tartrate and Timolol Maleate in bulk and ophthalmic preparations [PDF]
Monica Anwar+4 more
semanticscholar +3 more sources
Ocular Distribution of Brimonidine and Brinzolamide after Topical Instillation of a 0.1% Brimonidine Tartrate and 1% Brinzolamide Fixed-Combination Ophthalmic Suspension: An Interventional Study [PDF]
Purpose: To evaluate the concentrations of brimonidine and brinzolamide in the vitreous and aqueous humor after instillation of a 0.1% brimonidine tartrate and 1% brinzolamide fixed-combination ophthalmic suspension.
Yusuke Orii+7 more
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Efficient topical drug delivery remains a significant challenge in glaucoma management. Although nanoparticle formulations offer considerable promise, their complex preparation processes, co‐delivery issues, and batch consistency have hindered their ...
Da Huang+8 more
doaj +2 more sources
Novel long-acting brimonidine tartrate loaded-PCL/PVP nanofibers for versatile biomedical applications: fabrication, characterization and antimicrobial evaluation. [PDF]
The global state of antibiotic resistance highlights the necessity for new drugs that can treat a wide range of microbial infections. Drug repurposing has several advantages, including lower costs and improved safety compared to developing a new compound.
Salim SA+4 more
europepmc +2 more sources
Brimonidine tartrate-induced delayed hypersensitivity reaction
Chitaranjan Mishra+1 more
doaj +3 more sources
Preparation and Evolution of Soluble Ophthalmic Films of Brimonidine Tartrate In vitro
This study focuses on the treatment of Glaucoma with objectives overcomes certain disadvantages of Eye drops like the frequency of administration, drainage of medication by tear fluid, and greater therapeutic efficacy of drug (Brimonidine Tartrate) using
Michel Alhaddad, Mohammad Redzuan Othman
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