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Brincidofovir as Salvage Therapy for Adenovirus Disease in Intestinal Transplant Recipients
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2018BackgroundAdenoviruses are double‐stranded DNA viruses that typically cause mild self‐limiting respiratory, ocular, and gastrointestinal infections. In immunocompromised patients, especially transplant recipients, the infection can be severe, with dissemination and multiorgan failure. In intestinal transplant recipients, the incidence is as high as 57%.
Nimisha Sulejmani +6 more
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Expert Review of Anti-infective Therapy, 2014
CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate. The lipid conjugation results in oral bioavailability, higher intracellular concentrations of active drug, lower plasma concentrations of cidofovir and increased ...
Diana F, Florescu, Megan A, Keck
openaire +2 more sources
CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate. The lipid conjugation results in oral bioavailability, higher intracellular concentrations of active drug, lower plasma concentrations of cidofovir and increased ...
Diana F, Florescu, Megan A, Keck
openaire +2 more sources