Results 121 to 130 of about 33,910 (293)

Workflow to identify broadly neutralizing antibodies (bnAbs) from donor samples.

, 2023
(A) Serum neutralization profile of 4 cohort participants chosen for downstream analysis based on potent neutralizing activity against DENV1-4 and ZIKV.
Duncan K. Ralph (9248973), Veronica Duran (5943383), Benjamin J. Doranz (197292), Caroline Kikawa (6900701), Leslie Goo (3752755), Jay Lubow (772012), Lisa M. Levoir (17118305), Edgar Davidson (4692106), Fernando Rosso (2622862), Ana M. Sanz (2228902), Catiana H. Cartwright-Acar (12072728), Shirit Einav (142980), Laura Belmont (17118308), David E. Rebellon-Sanchez (17118314), Shruthi Kannan (14760434), Maya Contreras (17118311), Frederick A. Matsen IV (8212521)   +16 more
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses

, 2014
Includes bibliographical references.One of the greatest challenges for the development of an effective HIV-1 vaccine is the high genetic diversity of this pathogen and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoprotein ...
Essomba, Rene Ghislain
core  

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Antibody response to the hypervariable region-1 interferes with broadly neutralizing antibodies to hepatitis C virus

, 2016
International audienceABSTRACT Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 410) on the E2 glycoprotein of hepatitis C virus contributes to persistent infection by evolving escape mutations that attenuate binding of inhibitory antibodies and by
Lau, Patrick, Rey, Felix A, Foung, Steven K. H., Foung, Steven, K. H., Krey, Thomas, Keck, Zhen-yong, Girard-Blanc, Christine, Rey, Felix, A., Diamond, Michael S, Diamond, Michael, S., Wang, Wenyan, Zuiani, Adam   +11 more
core   +1 more source

Broadly Neutralizing Antibodies for Influenza: Passive Immunotherapy and Intranasal Vaccination

, 2020
Influenza viruses cause annual epidemics and occasional pandemics. The high diversity of viral envelope proteins permits viruses to escape host immunity.
Sachiko Akashi-Takamura, Tatsuya Yamazaki, Mrityunjoy Biswas, Joe Chiba   +3 more
core   +1 more source

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

Nature Communications, 2017
The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to induce
Alexander Rouvinski, Wanwisa Dejnirattisai, Pablo Guardado-Calvo, Marie-Christine Vaney, Arvind Sharma, Stéphane Duquerroy, Piyada Supasa, Wiyada Wongwiwat, Ahmed Haouz, Giovanna Barba-Spaeth, Juthathip Mongkolsapaya, Félix A. Rey, Gavin R. Screaton   +12 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness

, 2014
Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core  

Towards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies [PDF]

, 2011
Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far.
Joachim Denner, Denner, Joachim
core   +1 more source