Results 141 to 150 of about 33,910 (293)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

, 2008
A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV ...
Maruyama, T., Stamataki, Z., Fox, Robert I, Ball, Jonathan K, Burton, D. R., Giang, Erick, Francis V Chisari, Kneteman, Norman M, Lewis, J, Kneteman, N. M., McKeating, Jane A, Giang, E, Burton, Dennis R, Norman M Kneteman, Gastaminza, P., Tarr, Alexander W., Ian M Jones, Jonathan K Ball, Maruyama, Toshiaki, Burton, Dennis R., Jamie Lewis, Fox, R. I., Kneteman, NM, Law, M, Chisari, Francis V., Stamataki, Zacharenia, Robert I Fox, Zania Stamataki, Tarr, AW, Jones, IM, Lewis, J., Lewis, Jamie, Law, Mansun, McKeating, Jane, Pablo Gastaminza, Ball, J. K., McKeating, Jane A., Mansun Law, Chisari, FV, Law, M., Gastaminza, Pablo, Burton, DR, Chisari, Francis V, Ball, JK, Jones, Ian M., Tarr, A. W., Gastaminza, P, Fox, RI, Jones, Ian M, Dennis R Burton, Alexander W Tarr, Kneteman, Norman M., Chisari, F. V., Maruyama, T, McKeating, J. A., Tarr, Alexander W, Toshiaki Maruyama, Jane A McKeating, Giang, E., Erick Giang, Jones, I. M., Ball, Jonathan K., Fox, Robert I., Stamataki, Zania   +63 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Broadly Sarbecovirus-Neutralizing Antibodies Induced by Ancestral SARS-CoV-2 Infection

Viruses
The COVID-19 pandemic, driven by SARS-CoV-2, continues to challenge global health due to emerging variants and the potential risk posed by related sarbecoviruses.
Yiwei Zhang, Zhen Zhang, Feiyang Yu, Xianying Chen, Shangyu Yang, Jingyi Lin, Genmao Liu, Xinyang Liu, Ming Guo, Yu Chen, Ke Lan, Haiyan Zhao   +11 more
doaj   +1 more source

Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies.

, 2019
Broadly neutralizing antibodies are crucial for the control of many life-threatening viral infections like HIV, influenza, or hepatitis. Their induction is a prime goal in vaccine research.
Meyer-Hermann, Michael
core   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Plasma deconvolution identifies broadly neutralizing antibodies associated with hepatitis C virus clearance [PDF]

, 2019
A vaccine for hepatitis C virus (HCV) is urgently needed. Development of broadly neutralizing plasma antibodies during acute infection is associated with HCV clearance, but the viral epitopes of these plasma antibodies are unknown.
Bailey, Justin R., Colbert, Michelle D., Crowe, James E., Jr., Ray, Stuart C., Cox, Andrea L., Mankowski, Madeleine C., Massaccesi, Guido, Osburn, William O., Kinchen, Valerie J., Flyak, Andrew I.   +9 more
core  

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source