Results 161 to 170 of about 871,553 (293)

Vaccination elicits HIV broadly neutralizing antibodies in primates. [PDF]

Nature
Steichen JM, Madden PJ, Flynn CT, Phulera S, Shil M, Kalyuzhniy O, Liguori A, Kifude C, Sewall LM, Cottrell CA, Ma KM, Baboo S, Diedrich JK, McKenney K, deCamp AC, Carnathan DG, Phung I, Ramezani-Rad P, Marina-Zárate E, Freeman B, Xie Z, Lee JH, Sincomb T, Phelps N, Lu D, Goodwin D, Tingle R, Adachi Y, Alavi N, Tran J, Tran AS, Nascimento A, Sovie C, Bader DLV, Voic H, Zhou X, Pixton G, Walsh A, Melo MB, Schiffner T, Batista FD, Burton DR, Irvine DJ, Paulson JC, Yates JR, Ozorowski G, Ward AB, Silvestri G, Crotty S, Schief WR.   +49 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153

Recurrent mpox outbreaks caused by the monkeypox virus (MPXV) have prompted the World Health Organization to declare a Public Health Emergency of International Concern and have stimulated the development of medical interventions.
Gianesini, Natasha, Paciello I., Andreano E., Porrot, Françoise, Antinori, Spinello, Moschese D., Perrone F., Mullins, Connor M., Postal J., Passarelli Mantovani, Rebeca, Rappuoli R., Rundlet, Emily J., Perrone, Federica, Realini G., McLellan J. S., Realini, Giulia, Antinori S., Castilletti C., Troisi M., Montagnani, Francesca, Pierleoni G., Troisi, Marco, Rundlet E. J., Fabbiani, Massimiliano, Accordini, Silvia, Gianesini N., Fabbiani M., Paciello, Ida, Zhou, Ling, Sabaini F., Mullins C. M., Schwartz O., Panza, Francesca, Tumbarello M., Panza F., Montagnani F., Schwartz, Olivier, Postal, Jeanne, Moschese, Davide, Guivel-Benhassine F., Porrot F., Andreano, Emanuele, Castilletti, Concetta, Accordini S., Rappuoli, Rino, Sabaini, Federico, Guivel-Benhassine, Florence, Zhou L., Mantovani R. P., Tumbarello, Mario, Pierleoni, Giulio, McLellan, Jason S., Cossu M. V., Cossu, Maria Vittoria   +53 more
core   +1 more source

Broadly neutralizing antibodies for HIV therapy in clinical trials: a systematic review. [PDF]

Infect Dis Poverty
Zhao J, Wu H, He J, Luo Y, Liu J.
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Direct detection and quantification of HIV particles and their envelope trimers bound by combinations of broadly neutralizing antibodies. [PDF]

iScience
Dasgupta S, Srivatsav AT, Kumar S, Lewis GK, DeVico AL, Ray K.   +5 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Broadly neutralizing antibodies for treatment of HIV in children in the Global South: rationale and challenges. [PDF]

Front Pediatr
Tagarro A, Cobela-García A, Malhotra S, Chapman K, Rojo P.   +4 more
europepmc   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Structural basis of membrane engagement and polyreactivity control in HIV-1 MPER broadly neutralizing antibodies. [PDF]

Proc Natl Acad Sci U S A
Cho SY, Rantalainen K, Ozorowski G, Lu D, Tingle R, Lee WH, Ward AB, Schief WR, Wilson IA.   +8 more
europepmc   +1 more source