Results 51 to 60 of about 33,910 (293)

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells [PDF]

, 2008
Background: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses only provide efficient protection against a narrow spectrum of HA antigenic variants ...
Poon Leo L. M., Carsetti Rita, van der Meulen, J., Cinatl, J, Cox Freek, Guan, Yi, Ignace Lasters, Brink, Edward van den, van Deventer, W.B.E., Jongeneelen, M, ter Meulen Jan, Edward van den Brink, de Kruijf, C.G., de Kruif John, van Deventer, Els, Cinatl Jindrich, van Deventer, E, Peiris, M, Jaap Goudsmit, Carsetti, Rita, Throsby, Mark, Carsetti, R., Leo L M Poon, Cornelissen, L., Arjen Bakker, Kruijf, C.G., de, Throsby Mark, Lasters, I., Rita Carsetti, de Kruif, J, van den Brink, E., Poon, L.L.M., Freek Cox, Yi Guan, Goudsmit, J., Lisette Cornelissen, Els van Deventer, Cornelissen Lisette, de Kruif, John, Jongeneelen Mandy, Alard Philippe, Goudsmit Jaap, Guan Yi, Guan, Y, Alard, P., Brink, E., van den, ter Meulen, Jan, Peiris Malik, Deventer, Els van, Kruif, John de, Cinatl, J., John de Kruif, Jan ter Meulen, Cornelissen, L, Cox, F, Cox, Freek, Goudsmit, J, Cox, F., Poon, LLM, Bakker, A.B.H., Jindrich Cinatl, Lasters, Ignace, Jongeneelen, M., van Deventer Els, Mandy Jongeneelen, Poon, Leo L. M., Meulen, J., van der, Bakker, Arjen, Cinatl, Jindrich, van den Brink, E, Malik Peiris, Peiris, Malik, van den Brink Edward, Deventer, W.B.E., van, Bakker, A, van den Brink, Edward, Bakker Arjen, Mark Throsby, Throsby, M., Lasters, I, Guan, Y., Alard, Philippe, ter Meulen, J, Carsetti, R, Philippe Alard, Cornelissen, Lisette, Goudsmit, Jaap, Jongeneelen, Mandy, Peiris, M., Throsby, M, Meulen, Jan ter, Alard, P, Lasters Ignace   +92 more
core   +1 more source

Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]

, 2015
Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael, Ferrara, Francesca, Temperton, Nigel J., Flynn, Jessica A, Raghavan eVaradarajan, Vamsee Aditya Mallajosyula, V., Raghavan Varadarajan, Flynn, Jessica A., Temperton, Nigel J, Xiaoping eLiang, Vamsee Aditya Mallajosyula, V. Vamsee Aditya Mallajosyula, Michael Citron, Nigel J. Temperton, Xiaoping Liang, Mallajosyula, Vamsee Aditya V, Jessica A. Flynn, Liang, Xiaoping, Varadarajan, Raghavan, Michael eCitron, Francesca eFerrara, Nigel James Temperton, Jessica A Flynn, Francesca Ferrara, Mallajosyula, Vamsee V A   +24 more
core   +1 more source

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

PLoS ONE, 2019
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple
Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss   +11 more
doaj   +1 more source

A sweet surprise for HIV broadly neutralizing antibodies [PDF]

Nature Medicine, 2012
The production of cross-reactive neutralizing antibodies is the ultimate goal in HIV vaccine development, but no immunogen other than HIV itself has been able to elicit this type of humoral immunity. In natural HIV infections, these antibodies take several years to develop.
Langedijk, Johannes P. M., Schuitemaker, Hanneke   +1 more
openaire   +3 more sources

Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies

Frontiers in Immunology, 2014
Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutation on surface proteins of influenza virus result in increasing resistance to current vaccines and available antiviral drugs.
Jing eSun, Jing eSun, Ulrich eKudahl, Ulrich eKudahl, Zhiwei eCao, Christian eSimon, Christian eSimon, Ellis L Reinherz, Ellis L Reinherz, Ellis L Reinherz, Vladimir eBrusic, Vladimir eBrusic   +11 more
doaj   +1 more source

Recent progress in broadly neutralizing antibodies to HIV [PDF]

Nature Immunology, 2018
In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models ...
Devin Sok, Dennis R. Burton
openaire   +2 more sources

Role of HIV membrane in neutralization by two broadly neutralizing antibodies [PDF]

Proceedings of the National Academy of Sciences, 2009
Induction of effective antibody responses against HIV-1 infection remains an elusive goal for vaccine development. Progress may require in-depth understanding of the molecular mechanisms of neutralization by monoclonal antibodies. We have analyzed the molecular actions of two rare, broadly neutralizing, human monoclonal antibodies, 4E10 and 2F5, which ...
Alam, S. Munir, Morelli, Marco, Dennison, S. Moses, Liao, Hua-Xin, Zhang, Ruijun, Xia, Shi-Mao, Rits-Volloch, Sophia, Sun, Li, Harrison, Stephen C., Haynes, Barton F., Chen, Bing   +10 more
openaire   +4 more sources

Coevolution of HIV-1 and broadly neutralizing antibodies

Current Opinion in HIV and AIDS, 2019
Exploring the molecular details of the coevolution of HIV-1 Envelope with broadly neutralizing antibodies (bNAbs) in infected individuals over time provides insights for vaccine design. Since mid-2017, the number of individuals described in such publications has nearly tripled.
Nicole A, Doria-Rose, Elise, Landais
openaire   +3 more sources

SARS-CoV-2 fusion-peptide-directed antibodies are elicited by natural infection and can mediate broad sarbecovirus neutralization

Cell Reports
Summary: Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the development of antibodies capable of neutralizing
Alex L. Roederer, Chia Jung Li, Eunice Lim, Yi Cao, Larance Ronsard, Daniel Lingwood, David H. Canaday, Stefan Gravenstein, Alejandro B. Balazs   +8 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source