Results 81 to 90 of about 33,910 (293)

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

, 2022
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody-based ...
Farhat, Nisar, Lanzavecchia, Antonio, Sprouse, Kaitlin R; https://orcid.org/, Zatta, Fabrizia, Gustafsson, Claes, Ferrari, Paolo; https://orcid.org/, Sun, David, Yin, Li; https://orcid.org/, Logue, Jenni; https://orcid.org/, Culap, Katja; https://orcid.org/, VanBlargan, Laura A; https://orcid.org/, Saliba, Christian, Czudnochowski, Nadine, Rosen, Laura E; https://orcid.org/, Noack, Julia, Cippà, Pietro E; https://orcid.org/, Pizzuto, Matteo Samuele, di Iulio, Julia, De Marco, Anna, Silacci-Fregni, Chiara, Iqbal, Najeeha Talat, Franko, Nicholas M; https://orcid.org/, Ceschi, Alessandro; https://orcid.org/, Kaiser, Hannah; https://orcid.org/, Maher, Cyrus; https://orcid.org/, Garzoni, Christian; https://orcid.org/, Franzetti-Pellanda, Alessandra, Dillen, Josh R, Cameroni, Elisabetta, Pinto, Dora, Piccoli, Luca, Chen, Alex; https://orcid.org/, Bassi, Jessica, et al, Zepeda, Samantha K; https://orcid.org/, Soriaga, Leah; https://orcid.org/, Bowen, John E; https://orcid.org/, Powell, Abigail E, Havenar-Daughton, Colin; https://orcid.org/   +38 more
core   +1 more source

Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

PLoS Pathogens, 2014
To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas.
Laura E McCoy, Lucy Rutten, Dan Frampton, Ian Anderson, Luke Granger, Rachael Bashford-Rogers, Gillian Dekkers, Nika M Strokappe, Michael S Seaman, Willie Koh, Vanina Grippo, Alexander Kliche, Theo Verrips, Paul Kellam, Ariberto Fassati, Robin A Weiss   +15 more
doaj   +1 more source

Contribution of rare mutational outcomes to broadly neutralizing antibodies

Acta Biochimica et Biophysica Sinica, 2022
Antibodies are important immune molecules that are elicited by B cells to protect our bodies during viral infections or vaccinations. In humans, the antibody repertoire is diversified by programmed DNA lesion processes to ensure specific and high ...
Feng Anqi, Hao Qian, Yeap Leng-Siew
doaj   +1 more source

Multiple roles for HIV broadly neutralizing antibodies

Science Translational Medicine, 2019
Potent broadly neutralizing antibodies may be used to treat or prevent HIV and to help guide HIV vaccine design.
Barton F. Haynes, Dennis R. Burton, John R. Mascola   +2 more
openaire   +3 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Broadly Neutralizing Antibodies against HIV: Back to Blood [PDF]

Trends in Molecular Medicine, 2019
After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)].
Amir, Dashti, Anthony L, DeVico, George K, Lewis, Mohammad M, Sajadi   +3 more
openaire   +2 more sources

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Human monoclonal antibodies broadly neutralizing against influenza B virus. [PDF]

PLoS Pathogens, 2013
Influenza virus has the ability to evade host immune surveillance through rapid viral genetic drift and reassortment; therefore, it remains a continuous public health threat.
Mayo Yasugi, Ritsuko Kubota-Koketsu, Akifumi Yamashita, Norihito Kawashita, Anariwa Du, Tadahiro Sasaki, Mitsuhiro Nishimura, Ryo Misaki, Motoki Kuhara, Naphatsawan Boonsathorn, Kazuhito Fujiyama, Yoshinobu Okuno, Takaaki Nakaya, Kazuyoshi Ikuta   +13 more
doaj   +1 more source

Determinants of HIV-1 broadly neutralizing antibody induction [PDF]

Nature Medicine, 2016
Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systematic survey in 4,484 HIV-1-infected individuals that identified 239 bnAb inducers.
Peter Rusert, Roger D Kouyos, Claus Kadelka, Hanna Ebner, Merle Schanz, Michael Huber, Dominique L Braun, Nathanael Hozé, Alexandra Scherrer, Carsten Magnus, Jacqueline Weber, Therese Uhr, Valentina Cippa, Christian W Thorball, Herbert Kuster, Matthias Cavassini, Enos Bernasconi, Matthias Hoffmann, Alexandra Calmy, Manuel Battegay, Andri Rauch, Sabine Yerly, Vincent Aubert, Thomas Klimkait, Jürg Böni, Jacques Fellay, Roland R Regoes, Huldrych F Günthard, Alexandra Trkola, Heiner C Bucher, Angela Ciuffi, Günther Dollenmaier, Matthias Egger, Luigia Elzi, Jan Fehr, Hansjakob Furrer, Christoph A Fux, David Haerry, Barbara Hasse, Hans H Hirsch, Irene Hösli, Christian Kahlert, Laurent Kaiser, Olivia Keiser, Helen Kovari, Bruno Ledergerber, Gladys Martinetti, Begoña Martinez de Tejada, Catia Marzolini, Karin J Metzner, Nicolas Müller, Dunja Nicca, Giuseppe Pantaleo, Paolo Paioni, Christoph Rudin, Patrick Schmid, Roberto Speck, Marcel Stöckle, Philip Tarr, Pietro Vernazza, Gilles Wandeler, Rainer Weber   +61 more
openaire   +6 more sources