Results 51 to 60 of about 92,013 (336)

Efficient routes to epimerically-pure side-chain derivatives of lanosterol [PDF]

, 2004
A technically simple route is described to individual epimers of side-chain derivatives of lanosterol (3-hydroxy-5-lanosta-8,24-diene). Epimerically pure 24,25-epoxy-, 24,25-dihydroxy- and 24-bromo-25-hydroxy-lanosterol have been prepared in good yield ...
Kavtaradze, Levan K., Manley-Harris, Merilyn, Nicholson, Brian K.   +2 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis

Molecules, 2010
A practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of stable 2-pyridylzinc bromides and 3-pyridylzinc bromides.
Reuben D. Rieke, Seung-Hoi Kim
doaj   +1 more source

Oxidative monobromination of electron-​rich arenes by concentrate H2SO4​/alkali metal bromides [PDF]

, 2004
The reaction of electron-​rich arenes with alkali metal bromides such as sodium and potassium bromides in the presence of conc. H2SO4 to give p-​bromoarenes is reported. The reaction is possible in the absence of any specialized oxidizing agents and the
Myint Yi Yi, ., Pasha, M.A.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design

Química Nova, 2009
Pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. In the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with DCC/DMAP.
João Paulo dos Santos Fernandes, Veni Maria Andres Felli   +1 more
doaj   +1 more source

Cooperative effects in surfactant adsorption layers at water/alkane interfaces

, 2019
In the present work, the properties of dodecyl dimethyl phosphine oxide (C12DMPO) at the water/decane interface are studied and compared with those obtained earlier at the interface to hexane.
Aidarova, S., Aksenenko, E., Fainerman, V., Javadi, A., Makievski, A., Miller, R., Nikolenko, M., Sharipova, A.   +7 more
core   +1 more source

Synthesis and Diels-Alder Reactions of 1,2-Dimethylene- and 1,2,9,10-Tetramethylene-[2.2]paracyclophane: New Routes to Bridge-Anellated[2.2]Paracyclophanedienes [PDF]

, 1992
The title compounds 8 and 1 have been synthesized in three steps each from 1,2-dibromo[2.2]paracyclophan-1-ene (2) and 1,2,9,10-tetrabromo[2.2]paracyclophane-1,9-diene (4), respectively. Copper-mediated coupling of vinyl bromides 2 and 4 with methyl- and
Bailey, Beletskaya, Blatter, Blatter, Cava, Chan, Dalton, de Meijere, de Meijere, GröUtzmacher, Hopf, Hopf, Jenekhe, Keehn, Kohnke, KöUnig, Pollmann, Posner, Reiser, Sato, Scharf, SchlöUter, Stoddart, Stoddart, Stoddart, VöUgtle, Wagner, Wegner, Wong   +28 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Magnetism of CuX2 frustrated chains (X = F, Cl, Br): the role of covalency

, 2013
Periodic and cluster density-functional theory (DFT) calculations, including DFT+U and hybrid functionals, are applied to study magnetostructural correlations in spin-1/2 frustrated chain compounds CuX2: CuCl2, CuBr2, and a fictitious chain structure of ...
Janson, O., Lebernegg, S., Rosner, H., Schmitt, M., Tsirlin, A. A.   +4 more
core   +1 more source