Results 61 to 70 of about 11,829 (216)

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G. Moreels, Joris Messens, Ana Beloqui   +9 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

HGF/c‐Met Axis‐Targeted Nanotherapy via GSH‐Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis

Advanced Healthcare Materials, EarlyView.
To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao, Hanhan Liu, Hanchen Zhang, Hong Ren, Binyu Wen, Jing Zhang, Jiaqi Du, Ziyi Cai, Zhihong Deng   +8 more
wiley   +1 more source

Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies

Advanced Healthcare Materials, EarlyView.
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba, Ayşe Karakeçili, Berna Topuz, Barış Batur, Okan Onar, Mehmet Eray Elçiğir, Çağdaş Oto, Alireza Hanifehnezhad, Kaan Orhan   +8 more
wiley   +1 more source

Geometric Adjustment of T Cell‐Sensitive Nanorobots for Enhanced Stability

Advanced Healthcare Materials, EarlyView.
For the long‐term use of live dendritic cell (DC)‐based vaccines, nano bone marrow dendritic cell (BMDC) originated T cell activators (nano‐BOTs) are synthesized. The geometric properties of nanoparticles are precisely modulated, enhancing their stability and T cell activation capacity.
Yoojin Lee, Dahae Kim, Taihyun Kim, Chae‐Won Moon, Hyungseok Yong, Sung‐eun Heo, Bumgyu Choi, Yoogyeong Oh, Woojin Choi, Kyungtae Park, Sang‐Jun Ha, Jinkee Hong   +11 more
wiley   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew, Erlantz Lizundia, Mark J. MacLachlan   +2 more
wiley   +1 more source

Perovskite Light‐Emitting Diodes with Quantum Wires and Nanorods

Advanced Materials, EarlyView.
This review focuses on low‐dimensional perovskite materials and discusses their applications in light‐emitting diodes (LEDs). Special attention is given to the introduction of perovskite quantum wires and nanorods, two unique types of one‐dimensional (1D) materials, and their interesting optoelectronic properties.
Qianpeng Zhang, Daquan Zhang, Zebing Liao, Yang Bryan Cao, Mallem Kumar, Swapnadeep Poddar, Junchao Han, Ying Hu, Hualiang Lv, Xiaoliang Mo, Abhishek Kumar Srivastava, Zhiyong Fan   +11 more
wiley   +1 more source

Optoelectronic Devices for In‐Sensor Computing

Advanced Materials, EarlyView.
The raw data obtained directly from sensors in the noisy analogue domain is often unstructured, which lacks a predefined format or organization and does not conform to a specific data model. Optoelectronic devices for in‐sensor visual processing can integrate perception, memory, and processing functions in the same physical units, which can compress ...
Qinqi Ren, Chaoyi Zhu, Sijie Ma, Zhaoqing Wang, Jianmin Yan, Tianqing Wan, Weicheng Yan, Yang Chai   +7 more
wiley   +1 more source

The Deepest Blue: Major Advances and Challenges in Deep Blue Emitting Quasi‐2D and Nanocrystalline Perovskite LEDs

Advanced Materials, EarlyView.
In this review, the recent development of deep‐blue (≤465 nm) perovskite light‐emitting diodes (PeLEDs) are summarized, using different perovskite nanomaterials, including nanocrystals (NCs), quantum dots (QDs), nanoplatelets (NPLs), quasi‐2D thin film, 3D bulk thin film, as well as lead‐free perovskite nanomaterials.
Pui Kei Ko, Jianchao Ge, Pengbo Ding, Dezhang Chen, Hoi Lam Tammy Tsang, Nitish Kumar, Jonathan E. Halpert   +6 more
wiley   +1 more source