Results 31 to 40 of about 58,742 (212)

DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target

Epigenetics
This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used as outcome ...
Jiangyue Qin, Bi Ran, Lian Liu, Ping Li, Zhenni Chen, Diandian Li, Yongchun Shen, Fuqiang Wen   +7 more
doaj   +1 more source

Medical Causes of Hospitalisation among Patients with Bronchiectasis: A Nationwide Study in Japan

Pathogens
Purpose: Although the international guidelines for managing bronchiectasis are centred on preventing the exacerbation of bronchiectasis, the medical causes of admissions to hospital among patients with bronchiectasis have not been fully investigated ...
Akihiko Hagiwara, Hisayuki Shuto, Ryohei Kudoh, Shota Omori, Kazufumi Hiramatsu, Jun-ichi Kadota, Kiyohide Fushimi, Kosaku Komiya   +7 more
doaj   +1 more source

Gastro-oesophageal reflux disease increases healthcare use and medical costs in patients with bronchiectasis: a Korean nationwide population-based study

Therapeutic Advances in Gastroenterology, 2021
Background: Gastro-oesophageal reflux disease (GORD) is not only a common aetiology but also accompanying comorbidity of non-cystic fibrosis bronchiectasis (bronchiectasis).
Jai Hoon Yoon, Sang Hyuk Kim, Jiin Ryu, Sung Jun Chung, Youlim Kim, Chang Ki Yoon, Seung Won Ra, Yeon Mok Oh, Hayoung Choi, Hyun Lee   +9 more
doaj   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Clinical characteristics and outcome of non-cystic fibrosis bronchiectasis in children: A tertiary care perspective

SAGE Open Medicine
Introduction: Bronchiectasis is a chronic respiratory disease caused by various respiratory and systemic conditions. It is now considered a potentially reversible disease, particularly when diagnosed early and managed with appropriate respiratory care ...
Phanthila Sitthikarnkha, Apichaya Anekvorakul, Sirapoom Niamsanit, Leelawadee Techasatian, Suchaorn Saengnipanthkul, Rattapon Uppala   +5 more
doaj   +1 more source

Secondary Immunodeficiency and Non-cystic Fibrosis Bronchiectasis [PDF]

Tuberculosis and Respiratory Diseases
Bronchiectasis is a chronic respiratory disease characterized by abnormal dilation of the bronchi that causes cough, sputum, and recurrent infections. As it may be associated with various respiratory or systemic diseases, a critical aspect of managing ...
Sungmin Zo, Ji-Yong Moon, Kyung Hoon Min, Hyun Lee   +3 more
doaj   +1 more source

Performance of an Idiopathic Pulmonary Fibrosis–Derived Multibiomarker Panel for Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective To assess whether a panel of peripheral blood biomarkers associated with idiopathic pulmonary fibrosis (IPF) is also associated with interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) using three independent cohorts. Methods We first assessed the association of a panel of IPF‐associated biomarkers with prevalent ILD ...
Brent A. Luedders, Daniel Kass, Joshua F. Baker, Michael J. Duryee, Yangyuna Yang, Punyasha Roul, Halie Frideres, Katherine D. Wysham, Paul A. Monach, Andreas Reimold, Gail S. Kerr, Gary Kunkel, Grant W. Cannon, Scott M. Matson, Jill A. Poole, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England, Dana P. Ascherman   +18 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Pharmacokinetic modelling of intravenous immunoglobulin in children with primary immunodeficiencies and secondary antibody deficiencies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Children with primary immunodeficiency (PID) and secondary antibody deficiency (SAD) often require immunoglobulin replacement therapy due to low plasma immunoglobulin G (IgG) levels and recurrent infections. Existing pharmacokinetic models for immunoglobulin in PID patients predominantly focus on adults, with limited attention to ...
Iek Leng Cheng, Zhong Hui Huang, Austen Worth, Claire Booth, Joseph F. Standing   +4 more
wiley   +1 more source

Effect of radiological extent and severity of bronchiectasis on pulmonary function

Multidisciplinary Respiratory Medicine, 2011
Background The aim of this study was to ascertain the effect of the extent and severity of bronchiectasis as determined with high-resolution computed tomography (HRCT) on lung function in patients with pure bronchiectasis, bronchiectasis and asthma, and ...
Habesoglu Mehmet A, Tercan Fahri, Ozkan Ugur, Fusun Eyuboglu O   +3 more
doaj   +1 more source