Results 81 to 90 of about 42,702 (296)

Born high, born fast: Does highland birth confer a pulmonary advantage for sea level endurance?

open access: yesExperimental Physiology, EarlyView.
Abstract Less than 7% of the world's population live at an altitude above 1500 m. Yet, as many as 67% of medalists in the 2020 men's and women's Olympic marathon, and 100% of medalists in the 2020 men's and women's Olympic 5000 m track race may have been born or raised above this otherwise rare threshold.
Hunter L. Paris   +7 more
wiley   +1 more source

Gas exchange during exercise in habitually active asthmatic subjects [PDF]

open access: yes, 2005
We determined the relations among gas exchange, breathing mechanics, and airway inflammation during moderate- to maximum-intensity exercise in asthmatic subjects.
Dempsey, JA   +6 more
core   +1 more source

Neurocardiology: translational advancements and potential

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Afferent signalling pathways of the autonomic nervous system and their efferent targets in the heart, kidneys and vasculature. Abstract In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it ...
N. Herring   +13 more
wiley   +1 more source

The inhibitory effect of anti-allergic agent suplatast tosilate (IPD–1151T) on methacholine- and allergen-induced bronchoconstriction in sensitized mice

open access: yesMediators of Inflammation, 2000
The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (±)-[2-[4-(3-ethoxy–2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were ...
Kazuhito Asano   +5 more
doaj   +1 more source

Sulfonamide‐Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.
ABSTRACT The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets.
Nebih Lolak   +8 more
wiley   +1 more source

The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

open access: yesTherapeutic Advances in Respiratory Disease, 2009
Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin
Venessa Schelfhout   +4 more
doaj   +1 more source

A novel model of IgE-mediated passive pulmonary anaphylaxis in rats. [PDF]

open access: yesPLoS ONE, 2014
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction ...
Eva Wex   +3 more
doaj   +1 more source

Mechanical correlates of dyspnea in bronchial asthma. [PDF]

open access: yes, 2013
We hypothesized that dyspnea and its descriptors, that is, chest tightness, inspiratory effort, unrewarded inspiration, and expiratory difficulty in asthma reflect different mechanisms of airflow obstruction and their perception varies with the severity ...
A., Antonelli   +8 more
core   +1 more source

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