Results 1 to 10 of about 63,084 (302)

Managing bronchiolitis in pediatric patients: Current evidence

Indian Journal of Respiratory Care, 2022
Background: Acute bronchiolitis is an inflammatory process affecting small airways. Although most cases are self-limiting, it is still one of the most common causes of hospitalization below 24 months of age. Treatment is mainly supportive. The purpose of
Subhranshu Sekhar Dhal, Hiremath Sagar
doaj   +1 more source

Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway

Pharmaceuticals, 2021
Cucumis sativus L. is globally cultivated as an edible vegetable. Besides its nutritional benefits, it is used in traditional medicines against various ailments. The current study was designed to elucidate the multi-target mechanisms of a C.
Muqeet Wahid, Fatima Saqib, Hanadi Talal Ahmedah, Claudia Mihaela Gavris, Vincenzo De Feo, Mircea Hogea, Marius Moga, Radu Chicea   +7 more
doaj   +1 more source

Pharmacoepidemiology of Drug Exposure in Intubated and Non-Intubated Preterm Infants With Severe Bronchopulmonary Dysplasia

Frontiers in Pharmacology, 2021
Background: Infants with severe bronchopulmonary dysplasia (BPD) are commonly treated with off-label drugs due to lack of approved therapies. To prioritize drugs for rigorous efficacy and safety testing, it is important to describe exposure patterns in ...
T. Lewis, W. Truog, L. Nelin, N. Napolitano, R. L. McKinney, and on behalf of The BPD Collaborative   +5 more
doaj   +1 more source

Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial [PDF]

, 2013
PMCID: PMC3691177This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Merewood, AA Litonjua, Adrian R. Martineau, AE Millen, B Novakovic, BW Hollis, CA Camargo Jr, CA Camargo Jr, Chris J. Griffiths, Christina Yu, CK Yu, CR Gale, D Bikle, DD Johnson, DR Murdoch, E Cremers, E Hypponen, F Groenman, FD Martinez, G Devereux, GR Zosky, Heinz Fehrenbach, Jane C. Kirkby, Janet Stocks, John O. Warner, M Erkkola, MF Holick, MJ Ege, N Beydon, Richard Hooper, Robert J. Boyle, Seif O. Shaheen, SH Pearce, Sheree Poulton, Stephen Robinson, Stephen T. Goldring, SW Turner, X Liu, Y Miyake   +38 more
core   +9 more sources

Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity

Frontiers in Pharmacology, 2020
Local anesthetics (LAs), such as lidocaine and mexiletine, inhibit bronchoconstriction in asthmatics, but adverse effects limit their use for this specific clinical application.
Katharinne Ingrid Moraes Carvalho, Diego de Sá Coutinho, Humberto Cavalcante Joca, Artur Santos Miranda, Jader dos Santos Cruz, Emerson Teixeira Silva, Marcus Vinícius Nora Souza, Robson Xavier Faria, Patricia Machado Rodrigues e Silva, Jorge Carlos Santos Costa, Marco Aurélio Martins   +10 more
doaj   +1 more source

Possible Mechanisms Underlying the Antispasmodic, Bronchodilator, and Antidiarrheal Activities of Polarity–Based Extracts of Cucumis sativus L. Seeds in In Silico, In Vitro, and In Vivo Studies

Pharmaceuticals, 2022
Apart from the nutritional value, Cucumis sativus L. has also been used in the traditional medicine of Iran, Pakistan, and India. Its seeds are used by herbalists to treat gastrointestinal, respiratory, and urinary problems.
Muqeet Wahid, Fatima Saqib, Saeed Akhtar, Anam Ali, Polrat Wilairatana, Mohammad S. Mubarak   +5 more
doaj   +1 more source

Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
A Barbato, A Chetta, AL James, C Owens, C Ward, D Payne, DG Altman, DN Payne, HR Roberts, HW Chu, J de Blic, K Kasahara, KO McKay, P Jeffery, P Sullivan, PA de Jong, PG Woodruff, PK Jeffery, S Saglani, SA Little, SM Stick, TR Bai, V Marchac, Y Nakano   +23 more
core   +3 more sources

Economic Evaluation of an Asthma Therapy: Effect of Salmeterol on Loss of Labor Productivity in Japan

Allergology International, 2005
Background: Asthma can have a negative impact on the productivity of paid and unpaid individuals. In this study, we aimed to investigate the impact of salmeterol, which, in recent years, has become available for the treatment of asthma in Japan, on the ...
Takehiko Miyagawa, Shuzo Nishimura
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease [PDF]

, 2013
The aim of the study was to characterize pharmacokinetics of tiotropium solution 5 µg compared to powder 18 µg and assess dose-dependency of tiotropium solution pharmacodynamics in comparison to placebo.
Cornelissen, PJG, Derom, Eric, Disse, B, Hohlfeld, JM, Peterkin, V, Sharma, A, Towse, L, van Noord, JA   +7 more
core   +1 more source

Bronchodilatory and B-adrenergic effects of methanolic and aqueous extracts of Althaea root on isolated tracheobronchial smooth rat muscle

Advanced Biomedical Research, 2015
Background: The smooth muscle contractions of the tracheobronchial airways are mediated through the balance of adrenergic, cholinergic and peptidergic nervous mechanisms.
Behrang Alani, Mohammad Zare, Mahdi Noureddini   +2 more
doaj   +1 more source