The future of bronchodilation: looking for new classes of bronchodilators [PDF]
Available bronchodilators can satisfy many of the needs of patients suffering from airway disorders, but they often do not relieve symptoms and their long-term use raises safety concerns. Therefore, there is interest in developing new classes that could help to overcome the limits that characterise the existing classes.At least nine potential new ...
Cazzola, Mario+2 more
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Testing bronchodilator responsiveness [PDF]
Neither flow-related nor volume-related bronchodilator reversibility were independently associated with the symptom burden, health status or dyspnoea in the COPD populationhttp://bit.ly ...
Judith Garcia-Aymerich+12 more
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COPD: maximization of bronchodilation [PDF]
The most recent guidelines define COPD in a multidimensional way, nevertheless the diagnosis is still linked to the limitation of airflow, usually measured by the reduction in the FEV1/FVC ratio below 70%. However, the severity of obstruction is not directly correlated to symptoms or to invalidity determined by COPD.
Stefano Nardini+9 more
openaire +7 more sources
Triple Therapy of Fluticasone Furoate, Umeclidinium, Vilanterol- A Compelling Choice in Severe Chronic Obstructive Pulmonary Disease [PDF]
Trelegy Ellipta (GlaxoSmithKlineTM) is the first single inhaler triple combination therapy comprising of umeclidinium, vilanterol and fluticasone approved by the United States Food and Drug Administration (US FDA) for patients with severe COPD in 2019.
B Jagan Nathan+4 more
doaj +1 more source
Nebuliser therapy in the intensive care unit [PDF]
The relationship between identity, lived experience, sexual practices and the language through which these are conveyed has been widely debated in sexuality literature.
O'Doherty, M.J., Thomas, S.H.L.
core +4 more sources
Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD [PDF]
Date of Aceptance: 12/02/2015 Acknowledgments The authors were assisted in the preparation of the manuscript by Sarah Filcek, a professional medical writer at CircleScience (Tytherington, UK), part of KnowledgePoint360, an Ashfield Company.
Beeh, Kai M+3 more
core +1 more source
Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts
Background: Interleukin (IL)-26 is a neutrophil-mobilizing and bactericidal cytokine that is enhanced in human airways in vivo in response to endotoxin from Gram-negative bacteria.
Karlhans Fru Che+4 more
doaj +1 more source
Bronchodilator reversibility in asthma and COPD: findings from three large population studies
Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway diseases. The aim of this investigation was to compare different methods for measuring BDR in participants with asthma and chronic obstructive pulmonary disease ...
C. Janson+18 more
semanticscholar +1 more source
Background: Asthma can have a negative impact on the productivity of paid and unpaid individuals. In this study, we aimed to investigate the impact of salmeterol, which, in recent years, has become available for the treatment of asthma in Japan, on the ...
Takehiko Miyagawa, Shuzo Nishimura
doaj +1 more source
Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
A Barbato+23 more
core +3 more sources