Results 21 to 30 of about 1,141,798 (294)
Nature Communications, 2022 The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of thermogenic capacity in interscapular BAT of ...
Shengnan Liu +22 more
semanticscholar +1 more source
Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis. [PDF]
Front Endocrinol (Lausanne), 2021 The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation.
Muley C, Kotschi S, Bartelt A.
europepmc +9 more sources
The Therapeutic Potential of Brown Adipocytes in Humans [PDF]
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of obesity ...
Craig ePorter +6 more
openaire +6 more sources
Scientific Reports, 2022 Human brown fat is a potential therapeutic target for preventing obesity and related metabolic diseases by dissipating energy as heat through uncoupling protein 1 (UCP1).
Y. Takeda, P. Dai
semanticscholar +1 more source
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Vaclav Babuska +7 more
openaire +4 more sources
Diabetes, 2020 Circulating branched-chain amino acids (BCAAs) associate with insulin resistance and type 2 diabetes. 3-Hydroxyisobutyrate (3-HIB) is a catabolic intermediate of the BCAA valine. In this study, we show that in a cohort of 4,942 men and women, circulating
Mona S. Nilsen +18 more
semanticscholar +1 more source
Src family kinases suppress differentiation of brown adipocytes and browning of white adipocytes [PDF]
Genes to Cells, 2016 Brown adipocytes and beige adipocytes can expend energy, generate heat, and increase whole‐body energy expenditure. The detailed mechanisms of adipogenesis and thermogenesis of these cells are still obscure. Here, we show that Src family kinases (SFKs) regulate both brown adipogenesis and browning of white adipocytes.
Masaharu Uno, Mai Usui, Eisuke Nishida
openaire +3 more sources
Cinnamon induces browning in subcutaneous adipocytes [PDF]
Scientific Reports, 2017 AbstractBrowning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract.
Anfernee Kai-Wing Tse +11 more
openaire +4 more sources
Genetic Studies of Brown Adipocyte Induction
The Journal of Nutrition, 2000 We seek to discover an effective method for utilizing thermogenesis to reduce the caloric load in obese individuals. Experimental evidence indicates that nonshivering thermogenesis is the most effective cellular and biochemical mechanism known for reducing excessive adiposity. In this presentation, we describe our experiments aimed at understanding how
Leslie P. Kozak
openalex +4 more sources
Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats
Frontiers in Endocrinology, 2022 Bone marrow adipose tissue has brown fat characteristics. Several studies have demonstrated that total flavonoids of Epimedium (TFE) could prevent bone loss and reduce the white adiposity in bone marrow induced by ovariectomy (OVX) in rats.
Lei Chen +8 more
doaj +1 more source