Results 131 to 140 of about 39,242 (266)

Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds

Scientific Reports, 2017
Brown adipocytes play an important role in human energy metabolism and prevention of obesity and diabetes. Induced pluripotent stem cells (iPSCs) represent a promising source for brown adipocytes; however, exogenous gene induction is generally required ...
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai   +3 more
doaj   +1 more source

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes

Cell Reports, 2017
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity.
Alfred K. Ramirez, Matthew D. Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif, Jonathan M. Dreyfuss   +7 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis

Molecular Metabolism, 2018
Objective: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN ...
Adilson Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, Michael P. Czech   +8 more
doaj   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Regulation of Intracellular Calcium in Brown Adipocytes [PDF]

, 1999
Intracellular Ca2+ is considered a primary regulator of cell function. In the present study, the control and the effects of intracellular Ca2+ in brown adipocytes have been investigated.
Wang, Lawrence C.H,, Zhang, Shi-Jin,
core  

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages [PDF]

, 2007
Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and increased energy expenditure potential, is a legitimate strategy for combating obesity.
Nedergaard, Jan,, Hamilton, D. Lee, Gimeno, RE, Petrovic, Natasa,, Hamilton, DL, Timmons, James A., Hamilton, D Lee, Wahlestedt, Claes, Timmons, JA, Larsson, Ola, Wahlestedt, C, Walden, Tomas B., Petrovic, N, Timmons, James A, Walden, Tomas B,, Lassmann, T, Lassmann, Timo, Wennmalm, Kristian, Walden, TB, Gimeno, Ruth E, Baar, Keith, Baar, K, Nedergaard, Jan, Gimeno, Ruth E., Wennmalm, K,, Hamilton, David Lee, Cannon, Barbara,, Walden, Tomas B, Petrovic, Natasa, Cannon, Barbara, Larsson, O,   +30 more
core   +1 more source

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Journal of Experimental & Clinical Cancer Research, 2019
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang   +10 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The origin of lipofuscin in brown adipocytes of hyperinsulinaemic rats: The role of lipid peroxidation and iron [PDF]

, 2013
The aim of this study was to investigate lipofuscin origin in brown adipocytes of hyperinsulinaemic rats and the possible role of lipid peroxidation and iron in this process.
Korać, Bato, Stancic, Ana, Veličković, Ksenija, Klepal, Waltraud, Golić, Igor, Korać, Aleksandra, Markelić, Milica, Otasevic, Vesna, Jankovic, Aleksandra, Vucetic, Milica, Buzadzic, Biljana   +10 more
core   +1 more source