Results 1 to 10 of about 156,812 (114)

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]

, 2013
Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y., Froehlich, H., Haas, B., Kipschull, S., Meister, G., Pfeifer, A., Siegel, F.   +6 more
core   +1 more source

Brown adipose tissue [PDF]

, 2012
Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure,
Townsend, Kristy L, Tseng, Yu-Hua
core   +1 more source

Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs [PDF]

, 1993
Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous ...
Arthur, John R., Duncan, Jacqueline S., Nicol, Fergus, Thomas, Moira E.A., Trayhurn, Paul   +4 more
core   +1 more source

miR-34a-/- mice are susceptible to diet-induced obesity [PDF]

, 2016
Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H., Caslake, Muriel, Collier, Andrew, Donnelly, Iona, Holmes, William, Kurowska-Stolarska, Mariola, Lavery, Christopher A., Miller, Ashley M.   +7 more
core   +1 more source

Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]

, 2016
To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel, Gondret, Florence, Louveau, Isabelle, Perruchot, Marie-Hélène   +3 more
core   +3 more sources

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources

Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β-adrenoceptor agonist [PDF]

, 1984
The maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates.
Cawthorne, M.A., Levy, Alison L., Wilson, Karen, Young, P.   +3 more
core   +1 more source

Intravitreally injected anti-VEGF antibody reduces brown fat in neonatal mice [PDF]

, 2015
Anti-vascular endothelial growth factor (VEGF) agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a ...
A Hellstrom, AL Hard, AM Cypess, B Cannon, BJ Lee, Chang Sik Cho, D Lepore, DF Martin, DH Jo, Dong Hyun Jo, H Kim, HA Mintz-Hittner, HA Mintz-Hittner, HK Sung, I Elias, I Shimizu, J Qian, Jeong Hun Kim, JH Kim, Jin Hyoung Kim, K Sun, L Sidossis, LA Kim, LE Smith, M Bagchi, M Tolentino, Marcus Fruttiger, Marià Alemany, MB Powner, Michael B. Powner, MO Stefanini, MS Gordon, P van Wijngaarden, RL Avery, RL Avery, Sung Wook Park, T Miyake, T Sato, WC Wu, Y Cao, Y Xue   +40 more
core   +10 more sources

Brown vs white adipocytes: The PPARγ coregulator story [PDF]

, 2010
The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors.
Kalkhoven, Eric, Koppen, Arjen
core   +1 more source

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]

, 2017
BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P, Danai, Laura V, Guilherme, Adilson, Henchey, Elizabeth, Henriques, Felipe S, Jung, DaeYoung, Kim, Jason K, Lodhi, Irfan J, Pedersen, David J, Semenkovich, Clay F, Shen, Yuefei, Yenilmez, Batuhan   +11 more
core   +4 more sources