Results 11 to 20 of about 292,612 (343)

Brown adipose tissue monocytes support tissue expansion [PDF]

Nature Communications, 2021
Adipose tissue is composed of a number of adipocytes and a number of other cells including immune cells. Here the authors use single-cell sequencing of murine brown adipose tissue immune cells and describe multiple macrophage and monocyte subsets and ...
Alexandre Gallerand, Marion I. Stunault, Johanna Merlin, Hannah P. Luehmann, Deborah H. Sultan, Maria M. Firulyova, Virginie Magnone, Narges Khedher, Antoine Jalil, Bastien Dolfi, Alexia Castiglione, Adelie Dumont, Marion Ayrault, Nathalie Vaillant, Jérôme Gilleron, Pascal Barbry, David Dombrowicz, Matthias Mack, David Masson, Thomas Bertero, Burkhard Becher, Jesse W. Williams, Konstantin Zaitsev, Yongjian Liu, Rodolphe R. Guinamard, Laurent Yvan-Charvet, Stoyan Ivanov   +26 more
doaj   +7 more sources

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation[S] [PDF]

Journal of Lipid Research, 2018
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade
Petra Kotzbeck, Antonio Giordano, Eleonora Mondini, Incoronata Murano, Ilenia Severi, Wiebe Venema, Maria Paola Cecchini, Erin E. Kershaw, Giorgio Barbatelli, Guenter Haemmerle, Rudolf Zechner, Saverio Cinti   +11 more
doaj   +5 more sources

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +2 more sources

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.

Cell Metabolism, 2022
Recent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain ...
M. Rosina, Veronica Ceci, Riccardo Turchi, L. Chuan, Nicholas Borcherding, F. Sciarretta, María Sánchez-Díaz, Flavia Tortolici, Keaton Karlinsey, V. Chiurchiù, C. Fuoco, Rocky Giwa, Rachael L. Field, M. Audano, Simona Arena, A. Palma, Federica Riccio, F. Shamsi, G. Renzone, Martina Verri, A. Crescenzi, S. Rizza, F. Faienza, G. Filomeni, S. Kooijman, S. Rufini, A. D. de Vries, A. Scaloni, N. Mitro, Y. Tseng, A. Hidalgo, Beiyan Zhou, Jonathan R. Brestoff, K. Aquilano, Daniele Lettieri-Barbato   +34 more
semanticscholar   +3 more sources

Deceptive Brown Adipose Tissue

Journal of the ASEAN Federation of Endocrine Societies
A 23-year-old female presented with headache, palpitation, and hypertensive spells. There was no similar family history. Twenty-four (24) hour urine testing showed elevated normetanephrine level with normal metanephrines [metanephrines 123 mcg/24 hrs ...
Biswajit Payra, Abhranil Dhar, Pankaj Singhania, Akshay Khatri, Pranab Kumar Sahana   +4 more
doaj   +3 more sources

SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue [PDF]

Nature Communications
Brown adipose tissue is an evolutionary innovation in placental mammals that regulates body temperature through adaptive thermogenesis. Cold exposure activates brown adipose tissue thermogenesis through coordinated induction of brown adipogenesis ...
Tamires Duarte Afonso Serdan, Heidi Cervantes, Benjamin Frank, Akhil Gargey Iragavarapu, Qiyu Tian, Daniel Hope, Chan Hee J. Choi, Anne Hoffmann, Adhideb Ghosh, Christian Wolfrum, Matthew B. Greenblatt, Paul Cohen, Matthias Blüher, Halil Aydin, Gary J. Schwartz, Farnaz Shamsi   +15 more
doaj   +2 more sources

The dorsal aortic compartment is a developmental source of brown adipose tissue in mice [PDF]

Nature Communications
White adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are ...
Sophie Heider, Cornelius Fischer, Ali Kerim Secener, Pedro Vallecillo-Garcı́a, Georgios Kotsaris, Zarah G. Meisen, Verena Pawolski, Claudia Giesecke-Thiel, Thomas Conrad, Tim J. Schulz, Sascha Sauer, Sigmar Stricker   +11 more
doaj   +2 more sources

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

Molecular Metabolism, 2019
Objective: Increasing the amounts of functionally competent brown adipose tissue (BAT) in adult humans has the potential to restore dysfunctional metabolism and counteract obesity.
Naja Z. Jespersen, Amir Feizi, Eline S. Andersen, Sarah Heywood, Helle B. Hattel, Søren Daugaard, Lone Peijs, Per Bagi, Bo Feldt-Rasmussen, Heidi S. Schultz, Ninna S. Hansen, Rikke Krogh-Madsen, Bente K. Pedersen, Natasa Petrovic, Søren Nielsen, Camilla Scheele   +15 more
doaj   +2 more sources

BATLAS: Deconvoluting Brown Adipose Tissue [PDF]

Cell Reports, 2018
Summary: Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies ...
Aliki Perdikari, Germán Gastón Leparc, Miroslav Balaz, Nuno D. Pires, Martin E. Lidell, Wenfei Sun, Francesc Fernandez-Albert, Sebastian Müller, Nassila Akchiche, Hua Dong, Lucia Balazova, Lennart Opitz, Eva Röder, Holger Klein, Patrik Stefanicka, Lukas Varga, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Markku Taittonen, Gottfried Rudofsky, Jozef Ukropec, Sven Enerbäck, Elia Stupka, Heike Neubauer, Christian Wolfrum   +25 more
doaj   +5 more sources

White and brown adipose tissue share a convergent fibro-adipogenic progenitor population [PDF]

EMBO Reports
Adipose tissue heterogeneity has emerged as a central factor in regulating adipose tissue function in physiology and pathophysiology, yet tools to model and study this diversity in vitro remain limited.
Hoang V Bui, Julia K Hansen, Valentina Lo Sardo, Andrea Galmozzi   +3 more
doaj   +2 more sources