Results 211 to 220 of about 292,612 (343)

Cdkn2a deficiency promotes adipose tissue browning

, 2017
Nabil Rabhi, Sarah Anissa Hannou, Xavier Gromada, Elisabet Salas, Xi Yao, Frédérik Oger, Charlène Carney, Isabel C. López‐Mejía, Emmanuelle Durand, Iandry Rabearivelo, Amélie Bonnefond, Émilie Caron, Lluís Fajas, Christian Dani, Philippe Froguel, Jean‐Sébastien Annicotte   +15 more
openalex   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Editorial: Dietary influences on white and brown adipose tissue: mechanisms and health implications. [PDF]

Front Nutr
Reymond Simoes M, Bombassaro B, Monfort-Pires M.   +2 more
europepmc   +1 more source

Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice

, 2017
Takayuki Ohtomo, Kanako Ino, Ryota Miyashita, Maya Chigira, Masahiko Nakamura, Koji Someya, Niro Inaba, Mariko Fujita, Mitsuhiro Takagi, Junji Yamada   +9 more
openalex   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. [PDF]

Elife
Izumi-Mishima Y, Tsutsumi R, Shiuchi T, Fujimoto S, Taniguchi M, Sugiuchi M, Tsutsumi M, Okamatsu-Ogura Y, Yoneshiro T, Kuroda M, Nomura K, Sakaue H.   +11 more
europepmc   +1 more source

Is stimulation of browning of human adipose tissue a relevant therapeutic target?

André C. Carpentier, Denis P. Blondin
openalex   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue. [PDF]

PLoS Biol
Zhang X, Jiang T, Wang C, Montenegro Vazquez VF, Wu D, Yang X, Le Q, Sun MS, Wang X, Yang XO, Pu J, Campen M, Feng C, Liu M.   +13 more
europepmc   +1 more source

Causal role of genetically predicted impairment of branched‐chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Elevated branched‐chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β‐cell and peripheral insulin resistance. Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear.
Xiangyu Zhou, Jiawen Lu, Zhenqian Wang, Kenneth King‐Yip Cheng, Gloria Hoi‐Yee Li   +4 more
wiley   +1 more source