Results 191 to 200 of about 77,500 (299)

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

ACLY Safeguards Copper Homeostasis to Sustain Brown Adipose Tissue Thermogenesis and Restrain Diet-Induced Obesity. [PDF]

Research (Wash D C)
Liu X, Jia L, Li L, Huang J, Hou M, Li Z, Yao D, Yang Y, Wang J, Dai L.   +9 more
europepmc   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue. [PDF]

J Mol Med (Berl)
Sood A, Peterson J, Jena J, Challa V, Washburn C, Seeley RJ, Pereira RO.   +6 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

PCB-126 exposure promotes brown adipose tissue dysfunction and metabolic inflexibility in mice. [PDF]

Sci Rep
Peixoto TC, Miranda CS, Teixeira AMR, Quitete FT, Teixeira AVS, Monteiro EB, Martins BC, de Castro Resende A, Martins FF, de Barros Mucci D, Daleprane JB.   +10 more
europepmc   +1 more source

Associations of finerenone with reduced insulin resistance in patients with type 2 diabetes and chronic kidney disease: A real‐world observational study

Journal of Diabetes Investigation, EarlyView.
This real‐world observational study enrolled 256 patients with type 2 diabetes and chronic kidney disease (T2D‐CKD). After 12 months of finerenone treatment, 45 patients completed follow‐up. Finerenone was associated with significant improvements in insulin resistance markers (HOMA‐IR, TyG index), lipid profile (LDL‐C), glycemic control (HbA1c), and ...
Xin Zhao, Bohan Liu, Ran Sun, Yaxuan Shi, Ya Liu   +4 more
wiley   +1 more source

Cordycepin Ameliorates Constant Light-Induced Thermogenic Dysfunction in Brown Adipose Tissue by Activating SIRT1-Mediated Mitochondrial Homeostasis. [PDF]

Int J Mol Sci
Bi Y, Zhang G, Wang Y, Zhang L, Wu S, Zhang Y, Li X, Yang D.   +7 more
europepmc   +1 more source

Integrative taxonomy reveals four new species of the armoured catfish genus Pareiorhina (Siluriformes: Loricariidae) from the upper Paraná River basin, Brazil

Journal of Fish Biology, EarlyView.
Abstract Four new species of the small‐sized armoured catfish genus Pareiorhina are described from mountain ranges in the Grande River drainage, upper Paraná River basin, based on morphological and molecular species delimitation methods. Molecular analyses based on the cytochrome oxidase subunit I (COI) marker recovered Pareiorhina as polyphyletic ...
Pedro L. C. Uzeda, Luana J. Sartori, Axel M. Katz, Felipe P. Ottoni, Wilson J. E. M. Costa, Francisco Langeani, Valter M. Azevedo‐Santos   +6 more
wiley   +1 more source

Acyl-CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice. [PDF]

Acta Physiol (Oxf)
Nørremark MF, Petersen R, Ruppert PMM, Jul ES, Doktor TK, Nielsen R, Kappel JF, Larsen S, Kornfeld JW, Mandrup S, Andresen BS, Havelund J, Neess D, Færgeman NJ.   +13 more
europepmc   +1 more source