Results 181 to 190 of about 77,500 (299)

PLIN1 associates with lipid droplets and mediates lipolysis in the perirenal brown adipose tissue of yak calves. [PDF]

Front Vet Sci
Bai Z, Fan W, Hao L, Shah AM, Chen F, Du J, Luo J, Yin Y, Hu Y, Tong Y.   +9 more
europepmc   +1 more source

Mitral regurgitation and decompensated heart failure in a young pregnant pony mare: An aetiological challenge

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David, L. Cannon, A. Tortereau, A. Thomas‐Cancian, I. Desjardins   +4 more
wiley   +1 more source

Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes. [PDF]

Cell Death Dis
Di Biagio C, Tortolici F, Gaudioso F, Ninni A, Giurdanella Annina F, De Ranieri C, Zaccaria F, Sciarretta F, Luca V, Arciprete F, Carotti S, Af de Vries A, Kooijman S, Pacello F, Battistoni A, Lettieri-Barbato D, Aquilano K.   +16 more
europepmc   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis. [PDF]

Physiol Rep
Taniguchi H, Hachikawa C, Iwase S, Nirengi S, Nagahata T.   +4 more
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

From brown to white: Brown adipose tissue endothelial cells whiten in culture conditions. [PDF]

Mol Metab
Elschner T, Grein S, Sander J, Hildebrand S, Heubach L, Pannwitz N, Mircea M, Raimundez E, Karagiannakou V, Georgiadi A, Heeren J, Hasenauer J, Pfeifer A, Wilhelm-Jüngling K.   +13 more
europepmc   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Dual Role of Transcription Factors in the Development and Thermogenic Function of Brown Adipose Tissue. [PDF]

Int J Med Sci
Wang S, Xie F, Li W, Xie W, Cheng H.
europepmc   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

The FEBS Journal, EarlyView.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source