Journal of Internal Medicine, EarlyView.Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple +25 more
wiley +1 more source
Brown adipose tissue-derived sEV-lncRNA Morrbid contributes to cold acclimation-induced cardioprotection against extreme cold. [PDF]
J Lipid ResZhang K +12 more
europepmc +1 more source
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger +5 more
wiley +1 more source
GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue. [PDF]
J Mol Med (Berl)Sood A +6 more
europepmc +1 more source
Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine +4 more
wiley +1 more source
ACLY Safeguards Copper Homeostasis to Sustain Brown Adipose Tissue Thermogenesis and Restrain Diet-Induced Obesity. [PDF]
Research (Wash D C)Liu X +9 more
europepmc +1 more source
Daridorexant‐ Case Report of Possible Side‐Effect in Rare Mitochondrial Disorder
Journal of Sleep Research, EarlyView.ABSTRACT This case report describes a 40‐year‐old woman with maternally inherited diabetes and deafness (MIDD), a rare mitochondrial disorder, who received treatment with daridorexant due to severe chronic insomnia. She developed progression of her MIDD symptoms during treatment.
Sven Svedmyr, Joel Bergqvist
wiley +1 more source
PCB-126 exposure promotes brown adipose tissue dysfunction and metabolic inflexibility in mice. [PDF]
Sci RepPeixoto TC +10 more
europepmc +1 more source
Associations Between Body Composition and Metabolic Health in Children With Obesity
Maternal &Child Nutrition, EarlyView.ABSTRACT Childhood obesity is an increasing public health problem with heterogeneous metabolic health outcomes. In children, distinguishing differences in body composition between individuals with metabolically healthy obesity (MHO) and those with metabolic syndrome (MS) may be useful for understanding the impact of body composition on metabolic health.
Desiree Lopez‐Gonzalez +5 more
wiley +1 more source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Obesity Reviews, EarlyView.ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source