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Brown adipose tissue functions in humans
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013Human adults have functionally active BAT. The metabolic function can be reliably measured in vivo using modern imaging modalities (namely PET/CT). Cold seems to be one of the most potent stimulators of BAT metabolic activity but other stimulators (for example insulin) are actively studied.
Kirsi A. Virtanen +2 more
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Brown Adipose Tissue. Interscapular Brown Adipose Tissue of the Rat
1985Brown or multilocular adipose tissue is relatively infrequent in man and is found predominantly in newborns. It occurs in the neck, armpit (Fig. A1), in the vicinity of the subclavian artery (Fig. A2) and kidney (Fig.A3), dorsal skin, mediastinum (Fig. A4), and mesenteries.
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Brown adipose tissue in humans
International Journal of Obesity, 2010Obesity is endemic in many regions of the world and a forerunner of several serious and sometimes fatal diseases such as ischemic heart disease, stroke, kidney failure and neoplasia. Although we know its origin--it results when energy intake exceeds energy expenditure--at present, the only proven therapy is bariatric surgery.
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2015
The second messenger cyclic guanosine monophosphate (cGMP) is a key mediator in physiological processes such as vascular tone, and its essential involvement in pathways regulating metabolism has been recognized in recent years. Here, we focus on the fundamental role of cGMP in brown adipose tissue (BAT) differentiation and function.
Christopher J. Larson +2 more
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The second messenger cyclic guanosine monophosphate (cGMP) is a key mediator in physiological processes such as vascular tone, and its essential involvement in pathways regulating metabolism has been recognized in recent years. Here, we focus on the fundamental role of cGMP in brown adipose tissue (BAT) differentiation and function.
Christopher J. Larson +2 more
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The Origins of Brown Adipose Tissue
New England Journal of Medicine, 2009Adipocytes that make up brown fat have two disparate lineages; one seems more closely related to muscle than to white adipose tissue.
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Brown Adipose Tissue Transplantation
2023The metabolic benefits of brown adipose tissue (BAT) are well known. Increasing the BAT content and/or activity is a proposed therapeutic approach to combat metabolic disease. Activation and induction of endogenous BAT have achieved varying degrees of success in correcting obesity, insulin resistance, and cardiovascular disease, with some limitations ...
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2017
Brown adipose tissue shows accumulation of FDG in normal fat tissue on PET/MR imaging that can be confusing to the inexperienced reader. Comparison of the fused PET/MR images with non-fused MR images helps differentiate brown fat from true lesions.
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Brown adipose tissue shows accumulation of FDG in normal fat tissue on PET/MR imaging that can be confusing to the inexperienced reader. Comparison of the fused PET/MR images with non-fused MR images helps differentiate brown fat from true lesions.
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Brown adipose tissue and lipid metabolism
Current Opinion in Lipidology, 2018Purpose of review This article explores how the interplay between lipid metabolism and thermogenic adipose tissues enables proper physiological adaptation to cold environments in rodents and humans. Recent findings Cold exposure triggers systemic changes in lipid metabolism, which ...
Joerg Heeren, Ludger Scheja
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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