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Functional brown adipose tissue in healthy adults.
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects.
K. Virtanen+10 more
semanticscholar +1 more source
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that
Yuqin Wang+8 more
semanticscholar +1 more source
Brown adipose tissue and thermogenesis [PDF]
Abstract The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled ...
Florian W. Kiefer, Anna Fenzl
openaire +3 more sources
Brown Adipose Tissue in a Newborn [PDF]
A premature infant boy of 35 weeks and 4 days weighing 2605 g was found to have bilateral supraclavicular masses at 13 days of life. He had persistent pulmonary hypertension of the newborn and thrombocytopenia. Delivery was by cesarean section for nonreassuring fetal status, and Apgar scores were 5 at 1 minute and 8 at 5 minutes. Initial radiographs
William G. Schucany, Brett W. Carter
openaire +3 more sources
Human Brown Adipose Tissue [PDF]
The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
openaire +3 more sources
Objective To study the changes in the metabolic activity of brown adipose tissues in a mouse model of progeria using Cerenkov luminescence imaging. Methods 18F-FDG PET/CT imaging and Cerenkov luminescence imaging were used to dynamically monitor the ...
WANG Zhengjie+4 more
doaj +1 more source
Bioengineering beige adipose tissue therapeutics
Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +1 more source
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura+6 more
doaj +1 more source
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo+14 more
wiley +1 more source
Casein Kinase 2—A Kinase that Inhibits Brown Fat Formation [PDF]
In adipose tissue, there is a delicate balance between storing and expending energy. In this issue, Shinoda et al. (2015) use phosphoproteomics to identify casein kinase 2 (CK2) as a suppressor of brown adipocyte formation, providing insights into how ...
Enerbäck, Sven
core +1 more source