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Science Signaling, 2022
The multilocular phenotype of brown adipose tissue is determined by an ER–lipid droplet anchoring protein.
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The multilocular phenotype of brown adipose tissue is determined by an ER–lipid droplet anchoring protein.
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ERRγ Preserves Brown Fat Innate Thermogenic Activity [PDF]
Cell Reports, 2018 Summary: Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport.
Eiji Yoshihara, Pooja Jha, Weiwei Fan
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Best Practice & Research Clinical Endocrinology & Metabolism, 2016
Ovarian steroids, such as estradiol (E2), control a vastness of physiological processes, such as puberty, reproduction, growth, development and metabolic rate. In fact, physiological, pathological, pharmacological or genetically-induced estrogen deficiency causes increased appetite and reduced energy expenditure, promoting weight gain and ultimately ...
Miguel López, Manuel Tena-Sempere
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Ovarian steroids, such as estradiol (E2), control a vastness of physiological processes, such as puberty, reproduction, growth, development and metabolic rate. In fact, physiological, pathological, pharmacological or genetically-induced estrogen deficiency causes increased appetite and reduced energy expenditure, promoting weight gain and ultimately ...
Miguel López, Manuel Tena-Sempere
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Nature, 1967
DAWKINS et al.1 have presented results of an investigation of the localization of catecholamines in brown fat, in which they used the histochemical fluorescence method of Falck and Hillarp2,3. They found a distinct fluorescence within the cytoplasm of the brown fat cells and in nerve fibres of the parenchyma.
C, Wirsén, B, Hamberger
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DAWKINS et al.1 have presented results of an investigation of the localization of catecholamines in brown fat, in which they used the histochemical fluorescence method of Falck and Hillarp2,3. They found a distinct fluorescence within the cytoplasm of the brown fat cells and in nerve fibres of the parenchyma.
C, Wirsén, B, Hamberger
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NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program [PDF]
Nature Cell Biology, 2017 Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis ...
Haruya Ohno +2 more
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1982
Publisher Summary Brown fat cells produce heat by oxidation of the fatty acids. Isolated cells are prepared by collagenase treatment of brown fat from hamsters and rats. The chapter outlines the isolation procedure for the brown fat cells and discusses the properties of the isolated cell suspension.
J, Nedergaard, O, Lindberg
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Publisher Summary Brown fat cells produce heat by oxidation of the fatty acids. Isolated cells are prepared by collagenase treatment of brown fat from hamsters and rats. The chapter outlines the isolation procedure for the brown fat cells and discusses the properties of the isolated cell suspension.
J, Nedergaard, O, Lindberg
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Annals of the New York Academy of Sciences, 2013
Nutrition plays a dominant role in human adaptation. Biological traits conferring these adaptations are of considerable significance. Within an obesogenic environment, there is considerable variation among individuals in their susceptibility to weight gain.
Dyan, Sellayah, Devanjan, Sikder
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Nutrition plays a dominant role in human adaptation. Biological traits conferring these adaptations are of considerable significance. Within an obesogenic environment, there is considerable variation among individuals in their susceptibility to weight gain.
Dyan, Sellayah, Devanjan, Sikder
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MicroRNAs in brown and beige fat
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019Brown adipose tissue (BAT) dissipates energy as heat and its activity correlates with leanness in human adults. Understanding the mechanisms behind the activation of BAT and the process of "browning", i.e. the appearance of inducible brown adipocytes called beige or brite (brown-in-white) cells in white adipose tissue (WAT), is of great interest for ...
Deborah, Goody, Alexander, Pfeifer
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Debugging the host browns the fat
Nature Medicine, 2015Microbiota depletion promotes type 2 cytokine signaling and browning in white adipose tissue of mice.
Beng San, Yeoh, Matam, Vijay-Kumar
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Energy Dissipation in Brown Fat
1978Heat evolution in isolated brown fat cells has been measured by microcalorimetry. Thermogenesis (= oxygen consumption) is enhanced in the presence of CO2. This effect is probably due to pyruvate carboxylase activity which will increase the mitochondrial concentration of oxaloacetate.
B, Cannon, J, Nedergaard
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