Results 61 to 70 of about 1,175 (153)

Nrf2 Activation in Inflammatory Diseases: A Review of Natural and Synthetic Modulators

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is a central regulator of the cellular antioxidant response, playing a key role in modulating inflammation and defending against oxidative stress‐induced damage. A range of natural and synthetic compounds, including dimethyl fumarate, bardoxolone, oltipraz, RTA‐408, ursodiol, curcumin ...
Vitória B. Costa, Iolanda A. F. de Matos, Isabela R. G. Nogueira, Mariely A. de Godoi, Fábio R. M. Leite, Morgana R. Guimarães-Stabili, Dario Ramirez   +6 more
wiley   +1 more source

Histone lactylation‐mediated up‐regulation of IGF2BP2 enhances ferroptosis resistance via Nrf2 in colorectal cancer

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
In the lactate‐rich tumor microenvironment, p300‐mediated H3K18la epigenetically activates IGF2BP2 transcription. The IGF2BP2 protein then stabilizes Nrf2 mRNA in the cytoplasm, leading to increased Nrf2 levels. This axis simultaneously confers ferroptosis resistance to cancer cells and promotes M2 macrophage polarization, fostering a malignant ...
Jin‐Feng Zhu, Da‐Peng Guo, Hai‐Na Lv, Zong‐Yu Liang, Jing Song, Wei Zeng   +5 more
wiley   +1 more source

Rifampicin attenuated global cerebral ischemia injury via activating the nuclear factor erythroid 2-related factor pathway

Frontiers in Cellular Neuroscience, 2016
Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear.
Beibei Chen, Huimin Cao, Lili Chen, Xuemei Yang, Xiaoyan Tian, Rong Li, Oumei Cheng   +6 more
doaj   +1 more source

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, Volume 69, Issue 16, August 2025.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Exploiting NRF2‐ARE pathway activation in papillary renal cell carcinoma

International Journal of Cancer, Volume 156, Issue 7, Page 1457-1469, 1 April 2025.
What's new? There are no targeted treatments available yet for papillary renal cell carcinoma (pRCC). Here, the authors investigate the NRF2‐ARE pathway as a possible source of therapeutic targets. The NRF2‐ARE pathway helps the cell detect and respond to increases in oxidative stress.
Silvia Angori, Harini Lakshminarayanan, Amir Banaei‐Esfahani, Katharina Mühlbauer, Hella Anna Bolck, Olli Kallioniemi, Vilja Pietiäinen, Peter Schraml, Holger Moch   +8 more
wiley   +1 more source

PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer. [PDF]

Biomed Pharmacother
Active targeting to cancer involves exploiting specific interactions between receptors on the surface of cancer cells and targeting moieties conjugated to the surface of vectors such that site-specific delivery is achieved. Prostate specific membrane antigen (PSMA) has proved to be an excellent target for active targeting to prostate cancer.
Adekiya TA, Hudson T, Bakare O, Ameyaw EE, Adebayo A, Olajubutu O, Adesina SK.   +6 more
europepmc   +3 more sources

Naturally Derived Terpenoids Targeting the 3D^pol of Foot-and-Mouth Disease Virus: An Integrated In Silico and In Vitro Investigation

Viruses
Foot-and-mouth disease virus (FMDV) belongs to the Picornaviridae family and is an important pathogen affecting cloven-hoof livestock. However, neither effective vaccines covering all serotypes nor specific antivirals against FMDV infections are ...
Natjira Mana, Sirin Theerawatanasirikul, Ploypailin Semkum, Porntippa Lekcharoensuk   +3 more
doaj   +1 more source