Results 71 to 80 of about 1,175 (153)

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

Frontiers in Pharmacology, 2018
Puerarin is an isoflavone isolated from Radix puerariae. Emerging evidence shown that puerarin possesses therapeutic benefits that aid in the prevention of cardiovascular diseases.
Shao-Ai Cai, Shao-Ai Cai, Ning Hou, Gan-Jian Zhao, Xia-Wen Liu, Ying-Yan He, Hai-Lin Liu, Yong-Quan Hua, Li-Rong Li, Yin Huang, Cai-Wen Ou, Cheng-Feng Luo, Min-Sheng Chen   +12 more
doaj   +1 more source

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis

Molecular & Cellular Proteomics, 2016
The KEAP1/Nrf2 pathway senses and responds to changes in intracellular oxidative stress. Mutations that result in constitutive activation of Nrf2 are present in several human tumors, especially non-small cell lung cancer. Therefore, compounds that inhibit Nrf2 activity might be beneficial in treating patients whose tumors show activation of this ...
Steffan, Vartanian, Taylur P, Ma, James, Lee, Peter M, Haverty, Donald S, Kirkpatrick, Kebing, Yu, David, Stokoe   +6 more
openaire   +2 more sources

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through up-regulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

Neural Regeneration Research
Memory loss and dementia are major public health concerns with a substantial economic burden. Oxidative stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory impairment.
Fahaid H AL-Hashem, Salah O Bashir, Amal F Dawood, Moutasem S Aboonq, Ismaeel Bin-Jaliah, Abdulaiziz M Al-Garni, Mohamed D Morsy   +6 more
doaj   +1 more source

The Nrf2/HO‐1 pathway participates in the antiapoptotic and anti‐inflammatory effects of platelet‐rich plasma in the treatment of osteoarthritis

Immunity, Inflammation and Disease
Introduction We aimed to explore the molecular mechanisms through which platelet‐rich plasma (PRP) attenuates osteoarthritis (OA)‐induced pain, apoptosis, and inflammation.
Guangyu Du, Xuegang Sun, Shengwei He, Lidong Mi   +3 more
doaj   +1 more source

Identity of Brusatol and Yatansin, An Antidysentric Agent

Agricultural and Biological Chemistry, 1980
SATO, Yukiharu, HASEGAWA, Masao, SUTO, Noriko   +2 more
openaire   +2 more sources

Therapeutic potential of dihydroartemisinin in mitigating radiation‐induced lung injury: Inhibition of ferroptosis through Nrf2/HO‐1 pathways in mice

Immunity, Inflammation and Disease
Background Radiation‐induced lung injury (RILI) is a common consequence of thoracic radiation therapy that lacks effective preventative and treatment strategies.
Xin Ning, Weidong Zhao, Qiaoyuan Wu, Cailan Wang, Shixiong Liang   +4 more
doaj   +1 more source

Carthamus tinctorius L. (Safflower) Flower Extract Attenuates Hepatic Injury and Steatosis in a Rat Model of Type 2 Diabetes Mellitus via Nrf2-Dependent Hypoglycemic, Antioxidant, and Hypolipidemic Effects

Antioxidants
This study aimed to examine the hepatic and anti-steatotic protective effects of methanolic extract from Carthamus tinctorius (safflower) flowers (SFFE), using a rat model of type 2 diabetes mellitus (T2DM), and to examine the molecular mechanisms ...
Nuha Saad Alshareef, Sahar Abdulaziz AlSedairy, Laila Naif Al-Harbi, Ghedeir M. Alshammari, Mohammed Abdo Yahya   +4 more
doaj   +1 more source

Brusatol hinders the advancement of bladder cancer by Chac1/Nrf2/SLC7A11 pathway

Abstract Background Bladder cancer, also known as BCa, is a common tumor that impacts the urinary system. It is marked by a significant fatality rate and an unfavorable outlook. Promising antineoplastic properties are exhibited by brusatol, which is obtained from the dried ripe fruit of Brucea javanica.
Xi Yu, ZIQI HE, QINGHUA WANG, SHUAI KE, HUAXIN WANG, ZHONG WANG, SHENGLAN LI   +6 more
openaire   +1 more source

Canagliflozin and Brusatol Synergize against LKB1-KEAP1 Co-Mutant NSCLC through AKT Suppression. [PDF]

Int J Biol Sci
Chen Y, Gao XZ, Rong D, Gao L, Tang M, Lu G, Ling ZQ, Shen HM.   +7 more
europepmc   +1 more source

Cafestol ameliorates diabetic nephropathy via Keap1-Nrf2 axis activation: A novel renoprotective mechanism independent of glycemic control. [PDF]

PLoS One
Sinan NA, Almujaydil MS.
europepmc   +1 more source