Results 91 to 100 of about 7,554 (201)

Multifaceted role of BTLA in the control of CD8+ T cell fate after antigen encounter [PDF]

, 2018
Purpose: Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown an overall clinical response rate 40%–50% in metastatic melanoma patients.
Bernatchez, Chantale, Vence, Luis M., Overwijk, William W., Varadarajan, Navin, Hailemichael, Yared, Aschenbrenner, Andrew, Hwu, Patrick, Zhang, Minying, Nurieva, Roza, Martinez-Paniagua, Melisa A., Roszik, Jason, Haymaker, Cara L., Radvanyi, Laszlo G., Ritthipichai, Krit, Yi, Xiaohui, Kale, Charuta   +15 more
core  

MOESM2 of BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes

, 2019
Additional file 2: Figure S2. Survival analysis of tumor-bearing mice undergoing various therapeutic agents combined with anti-BTLA Ab. (A) Survival analysis of mice treated with cisplatin and anti-BTLA Ab.
Han-Wei Lin (126608), Chi-An Chen (126605), Wen-Fang Cheng (126611), Yen-Ling Lai (7912607), Yu-Li Chen (126600), Chung-Liang Chien (126612), Wei-Zen Sun (300099)   +6 more
core   +1 more source

Characterisation of the expression and modulation of the HVEM-BTLA-ligand- receptor-system [PDF]

, 2009
Inhaltsverzeichnis 1 Abbildungsverzeichnis 5 Tabellenverzeichnis 6 1 Einleitung 7 1.1 Regulatorische Moleküle in der Immunantwort 7 1.2 HVEM und BTLA - Verbindung zwischen zwei Rezeptorfamilien 8 1.2.1 HVEM - Mitglied der TNF/TNFR-Superfamilie 8 1.2.2 ...
Worbs, Sylvia
core   +1 more source

Subset of DN Memory B Cells Expressing Low Levels of Inhibitory Receptor BTLA Is Enriched in SLE Patients

Cells
The dialogue between T and B cells can be regulated by different mechanisms, such as co-inhibitory receptors, which therefore play a crucial role in preventing autoimmune diseases such as systemic lupus erythematosus (SLE). B and T lymphocyte attenuator (
Lucie Aubergeon, Renaud Felten, Jacques-Eric Gottenberg, Hélène Dumortier, Fanny Monneaux   +4 more
doaj   +1 more source

A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α+ DCs to Promote Long-Term T Cell Responses [PDF]

, 2014
SummaryListeria monocytogenes infected CD8α+ DCs in the spleen are essential for CD8+ T cell generation. CD8α+ DCs are also necessary for Listeria expansion and dissemination within the host.
Tu, Tony, Tony Tu, Zhang, Xunmin, Yang-Xin Fu, Xuanming Yang, Yonglian Sun, Miller, Mendy, Fu, May Lynne, Sun, Yonglian, Fu, Yang-Xin, Mendy Miller, Yang, Xuanming, Xunmin Zhang, May Lynne Fu   +13 more
core   +1 more source

The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators [PDF]

In oral squamous cell carcinoma (OSCC) tissues, an immunotolerant situation triggered by immune checkpoints (ICPs) can be observed. Immune checkpoint inhibitors (ICIs) against the PD1/PD-L axis are used with impressive success. However, the response rate
Trumet, Leah, Ries, Jutta, Jutta Ries, Rainer Lutz, Leah Trumet, Kunater, Lina, Weber, Manuel, Marco Kesting, Lutz, Rainer, Manuel Weber, Geppert, Carol, Hahn, Alina, Alina Hahn, Lina Kunater, Carol Geppert, Kesting, Marco   +15 more
core   +1 more source

Functional studies on the receptor BTLA in a T cell reporter line

, 2018
Ein essentielles Kriterium für die Entstehung einer adäquaten Immunantwort durch T-Zellen ist das Zusammenspiel costimulatorischer und coinhibitorischer Signalmoleküle.
Hermann, Christina
core   +2 more sources

Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells

, 2018
International audienceCoinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation.
Sagez, Flora, Dumortier, Hélène, Gottenberg, Jacques-Eric, Fauny, Jean-Daniel, Sawaf, Matthieu, Monneaux, Fanny, Felten, Renaud   +6 more
core   +1 more source

BTLA expression in the host environment is required for expansion/survival of CD8 T cells.

, 2013
5×104 purified naïve CD45.1+ WT CD8+ OT-1 cells were adoptively transferred into WT or Btla−/− recipient mice. One day after transfer, mice were orally infected with 1×109 LM-OVA.
Yiran Wang-Zhu (478021), Carl F. Ware (49353), Yujun Huang (478020), Hilde Cheroutre (478022), Mitchell Kronenberg (79), Marcos W. Steinberg (49347)   +5 more
core   +1 more source

Distinct characteristics of BTLA/HVEM axis expression on Tregs and its impact on the expansion and attributes of Tregs in patients with active pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology
IntroductionPulmonary tuberculosis (PTB) remains one of the deadliest infectious diseases. Understanding PTB immunity is of potential value for exploring immunotherapy for treating chemotherapy-resistant PTB.
Peijun Tang, Peijun Tang, Xinghua Shen, Jianling Gao, Jianping Zhang, Yanjun Feng, Ji Zhang, Ziyi Huang, Ziyi Huang, Ziyi Huang, Xuefeng Wang   +10 more
doaj   +1 more source